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Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of in vitro, in vivo, and clinical trials

 Young Joo Han  ;  Keum Hwa Lee  ;  Sojung Yoon  ;  Seoung Wan Nam  ;  Seohyun Ryu  ;  Dawon Seong  ;  Jae Seok Kim  ;  Jun Young Lee  ;  Jae Won Yang  ;  Jinhee Lee  ;  Ai Koyanagi  ;  Sung Hwi Hong  ;  Elena Dragioti  ;  Joaquim Radua  ;  Lee Smith  ;  Hans Oh  ;  Ramy Abou Ghayda  ;  Andreas Kronbichler  ;  Maria Effenberger  ;  Daniela Kresse  ;  Sara Denicolò  ;  Woosun Kang  ;  Louis Jacob  ;  Hanwul Shin  ;  Jae Il Shin 
 THERANOSTICS, Vol.11(3) : 1207-1231, 2021-01 
Journal Title
Issue Date
Adenosine Monophosphate / analogs & derivatives ; Adenosine Monophosphate / therapeutic use ; Alanine / analogs & derivatives ; Alanine / therapeutic use ; Animals ; Antiviral Agents / therapeutic use* ; COVID-19 / mortality ; COVID-19 / therapy* ; Carbamates / therapeutic use ; Coronavirus Infections / mortality ; Coronavirus Infections / therapy* ; Disease Models, Animal ; Drug Combinations ; Drug Evaluation, Preclinical ; Drug Therapy, Combination / methods ; Humans ; Imidazoles / therapeutic use ; Immunization, Passive / methods ; Pyrrolidines / therapeutic use ; Randomized Controlled Trials as Topic ; Severe Acute Respiratory Syndrome / mortality ; Severe Acute Respiratory Syndrome / therapy* ; Sofosbuvir / therapeutic use ; Treatment Outcome ; Valine / analogs & derivatives ; Valine / therapeutic use
COVID-19 ; MERS ; SARS ; coronavirus ; mortality ; therapeutic agent
Rationale: Coronavirus disease 2019 (COVID-19) has spread worldwide and poses a threat to humanity. However, no specific therapy has been established for this disease yet. We conducted a systematic review to highlight therapeutic agents that might be effective in treating COVID-19. Methods: We searched Medline, Medrxiv.org, and reference lists of relevant publications to identify articles of in vitro, in vivo, and clinical studies on treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19 published in English until the last update on October 11, 2020. Results: We included 36 studies on SARS, 30 studies on MERS, and 10 meta-analyses on SARS and MERS in this study. Through 12,200 title and 830 full-text screenings for COVID-19, eight in vitro studies, 46 randomized controlled trials (RCTs) on 6,886 patients, and 29 meta-analyses were obtained and investigated. There was no therapeutic agent that consistently resulted in positive outcomes across SARS, MERS, and COVID-19. Remdesivir showed a therapeutic effect for COVID-19 in two RCTs involving the largest number of total participants (n = 1,461). Other therapies that showed an effect in at least two RCTs for COVID-19 were sofosbuvir/daclatasvir (n = 114), colchicine (n = 140), IFN-β1b (n = 193), and convalescent plasma therapy (n = 126). Conclusions: This review provides information to help establish treatment and research directions for COVID-19 based on currently available evidence. Further RCTs are required.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, Keum Hwa(이금화) ORCID logo https://orcid.org/0000-0002-1511-9587
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