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Comprehensive Analysis of Clinicopathologic Factors Predictive of an Unfavorable Prognosis in Patients With Acinic Cell Carcinoma of the Parotid Gland

Authors
 Young Min Park  ;  Sun Och Yoon  ;  Joo Hyun Kim  ;  Min Seok Kang  ;  Da Hee Kim  ;  Yoon Woo Koh  ;  Se-Heon Kim  ;  Jae-Yol Lim  ;  Eun Chang Choi 
Citation
 CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, Vol.14(1) : 108-115, 2021-02 
Journal Title
 CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY 
ISSN
 1976-8710 
Issue Date
2021-02
Keywords
Acinic Cell Carcinoma ; Parotid Gland ; Prognostic Factor
Abstract
Objectives: In subset of patients, acinic cell carcinoma (AcCC) exhibits aggressive features such as recurrence, distant metastasis, and mortality. This study aimed to investigate clinicopathologic factors influencing patients' prognosis and to identify adverse features predictive of an unfavorable prognosis. Methods: Between January 2000 and December 2016, 59 patients with AcCC were enrolled in this study. Results: The patients' 5-year overall survival rate was 93.3%, and their 5-year recurrence-free survival rate was 80.5%. During the study period, recurrence occurred in 10 patients. The mean time to recurrence after surgery was 26 months (range, 5-60 months). During the study period, three patients died from the disease. Univariate analysis showed that sex, surgical extent, extranodal extension, T classification, and TNM stage were significantly associated with disease recurrence. Multivariate analysis showed that, among the clinicopathologic factors included in the analysis, only TNM stage displayed a statistically significant correlation with disease recurrence. Conclusion: Surgical treatment alone yielded good results for AcCC, and additional treatment did not affect the recurrence-free survival rate or the overall survival rate, even when the resection margin was less than 1 mm. Other pathologic factors did not show prognostic significance for disease recurrence or death.
Files in This Item:
T202100893.pdf Download
DOI
10.21053/ceo.2019.01550
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koh, Yoon Woo(고윤우)
Kim, Da Hee(김다희) ORCID logo https://orcid.org/0000-0001-7286-1334
Kim, Se Heon(김세헌)
Kim, Joo Hyun(김주현) ORCID logo https://orcid.org/0000-0002-8533-9649
Park, Young Min(박영민) ORCID logo https://orcid.org/0000-0002-7593-8461
Yoon, Sun Och(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
Lim, Jae Yol(임재열) ORCID logo https://orcid.org/0000-0002-9757-6414
Choi, Eun Chang(최은창)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181902
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