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Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation

Authors
 Jin, Young  ;  Ji, Yul  ;  Song, Yaechan  ;  Choe, Sung Sik  ;  Jeon, Yong Geun  ;  Na, Heeju  ;  Nam, Tae Wook  ;  Kim, Hye Jeong  ;  Nahmgoong, Hahn  ;  Kim, Sung Min  ;  Kim, Jae-woo  ;  Nam, Ki Taek  ;  Seong, Je Kyung  ;  Hwang, Daehee  ;  Park, Chan Bae  ;  Lee, In Hye  ;  Kim, Jae Bum  ;  Lee, Han-Woong 
Citation
 DIABETES, Vol.70(1) : 182-195, 2021-01 
Journal Title
 DIABETES 
ISSN
 0012-1797 
Issue Date
2021-01
Abstract
Becn1/Beclin-1 is a core component of the class III phosphatidylinositol 3-kinase required for autophagosome formation and vesicular trafficking. Although Becn1 has been implicated in numerous diseases such as cancer, aging, and neurodegenerative disease, the role of Becn1 in white adipose tissue and related metabolic diseases remains elusive. In this study, we show that adipocyte-specific Becn1 knockout mice develop severe lipodystrophy, leading to adipose tissue inflammation, hepatic steatosis, and insulin resistance. Ablation of Becn1 in adipocytes stimulates programmed cell death in a cell-autonomous manner, accompanied by elevated endoplasmic reticulum (ER) stress gene expression. Furthermore, we observed that Becn1 depletion sensitized mature adipocytes to ER stress, leading to accelerated cell death. Taken together, these data suggest that adipocyte Becn1 would serve as a crucial player for adipocyte survival and adipose tissue homeostasis.
Full Text
https://diabetes.diabetesjournals.org/content/70/1/182
DOI
10.2337/db19-1239
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Jae Woo(김재우) ORCID logo https://orcid.org/0000-0001-5456-9495
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181847
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