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Screening of Tuberous Sclerosis-Associated Neuropsychiatric Disorders in Korea Using the TAND Checklist

Authors
 Soyoung Park  ;  Soyong Eom  ;  Hoon-Chul Kang  ;  Joon Soo Lee  ;  Heung Dong Kim  ;  Hee Jung Chung 
Citation
 Annals of Child Neurology, Vol.29(1) : 8-14, 2020-12 
Journal Title
 Annals of Child Neurology 
ISSN
 2035-909X 
Issue Date
2020-12
Keywords
Tuberous sclerosis ; Epilepsy ; Pediatrics ; Mental disorders
Abstract
Purpose: The present study aimed to elucidate the clinical characteristics of children with tuberous sclerosis complex (TSC) in Korea using the Tuberous Sclerosis-Associated Neuropsychiatric Disorders (TAND) checklist to evaluate the comorbidities of neurocognitive and socioemotional problems in the Korean clinical setting. Methods: A survey based on the TAND checklist was administered to 58 children with TSC receiving treatment on an outpatient basis. Their medical records and test results were retrospectively examined. Results: At the time of TAND administration, 35 (64.8%) of the participants had focal epilepsy, three (5.6%) had generalized epilepsy, six (11.1%) had infantile spasms, and seven (13.0%) had Lennox–Gastaut syndrome. The most frequently reported behavioral problem was difficulty getting on with other people of similar age (38/58, 65.5%). Twenty patients had received previous diagnoses of psychiatric disorders, six of whom had received two or more concurrent diagnoses. A further evaluation after testing with the TAND checklist identified new psychiatric disorders in two patients. Among the 35 children who underwent a formal evaluation of intelligence, 27 (77.1%) exhibited intellectual disability. Of the school-aged patients, 65.6% (21/32) experienced difficulties with mathematics and 56.3% (18/32) with spelling. Difficulty dual-/multi-tasking (27/58, 46.6%) and low self-esteem (18, 31.0%) were the most frequent neuropsychological and psychosocial issues, respectively. Conclusion: Our findings indicate that patients with TSC tend to experience neurocognitive and socioemotional difficulties, and regular screening for TAND using the TAND checklist can be helpful for managing children with TSC in the clinical setting.
Files in This Item:
T202005976.pdf Download
DOI
10.26815/acn.2020.00220
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181501
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