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Association of the Non-Motor Burden with Patterns of Striatal Dopamine Loss in de novo Parkinson's Disease

DC FieldValueLanguage
dc.contributor.author손영호-
dc.contributor.author유한수-
dc.contributor.author윤미진-
dc.contributor.author이양현-
dc.contributor.author이필휴-
dc.contributor.author이혜선-
dc.contributor.author정석종-
dc.date.accessioned2021-01-19T08:08:30Z-
dc.date.available2021-01-19T08:08:30Z-
dc.date.issued2020-10-
dc.identifier.issn1877-7171-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181477-
dc.description.abstractBackground: Striatal dopamine deficits play a key role in the pathogenesis of Parkinson's disease (PD), and several non-motor symptoms (NMSs) have a dopaminergic component. Objective: To investigate the association between early NMS burden and the patterns of striatal dopamine depletion in patients with de novo PD. Methods: We consecutively recruited 255 patients with drug-naïve early-stage PD who underwent 18F-FP-CIT PET scans. The NMS burden of each patient was assessed using the NMS Questionnaire (NMSQuest), and patients were divided into the mild NMS burden (PDNMS-mild) (NMSQuest score <6; n = 91) and severe NMS burden groups (PDNMS-severe) (NMSQuest score >9; n = 90). We compared the striatal dopamine transporter (DAT) activity between the groups. Results: Patients in the PDNMS-severe group had more severe parkinsonian motor signs than those in the PDNMS-mild group, despite comparable DAT activity in the posterior putamen. DAT activity was more severely depleted in the PDNMS-severe group in the caudate and anterior putamen compared to that in the PDMNS-mild group. The inter-sub-regional ratio of the associative/limbic striatum to the sensorimotor striatum was lower in the PDNMS-severe group, although this value itself lacked fair accuracy for distinguishing between the patients with different NMS burdens. Conclusion: This study demonstrated that PD patients with severe NMS burden exhibited severe motor deficits and relatively diffuse dopamine depletion throughout the striatum. These findings suggest that the level of NMS burden could be associated with distinct patterns of striatal dopamine depletion, which could possibly indicate the overall pathological burden in PD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherIOS Press-
dc.relation.isPartOfJOURNAL OF PARKINSONS DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAssociation of the Non-Motor Burden with Patterns of Striatal Dopamine Loss in de novo Parkinson's Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorSangwon Lee-
dc.contributor.googleauthorHan Soo Yoo-
dc.contributor.googleauthorYang Hyun Lee-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorYonghoon Choi-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorYoung H Sohn-
dc.identifier.doi10.3233/JPD-202127-
dc.contributor.localIdA01982-
dc.contributor.localIdA05367-
dc.contributor.localIdA05367-
dc.contributor.localIdA02550-
dc.contributor.localIdA02550-
dc.contributor.localIdA05714-
dc.contributor.localIdA05714-
dc.contributor.localIdA03270-
dc.contributor.localIdA03270-
dc.contributor.localIdA03312-
dc.contributor.localIdA03312-
dc.contributor.localIdA04666-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ01678-
dc.identifier.eissn1877-718X-
dc.identifier.pmid32925098-
dc.identifier.urlhttps://content.iospress.com/articles/journal-of-parkinsons-disease/jpd202127-
dc.subject.keywordDopamine transporter-
dc.subject.keywordParkinson’s disease-
dc.subject.keywordnon-motor-
dc.subject.keywordsubtype-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor정석종-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume10-
dc.citation.number4-
dc.citation.startPage1541-
dc.citation.endPage1549-
dc.identifier.bibliographicCitationJOURNAL OF PARKINSONS DISEASE, Vol.10(4) : 1541-1549, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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