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Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila

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dc.contributor.author문석준-
dc.date.accessioned2021-01-19T08:04:12Z-
dc.date.available2021-01-19T08:04:12Z-
dc.date.issued2020-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181451-
dc.description.abstractThe Drosophila lymph gland, the larval hematopoietic organ comprised of prohemocytes and mature hemocytes, has been a valuable model for understanding mechanisms underlying hematopoiesis and immunity. Three types of mature hemocytes have been characterized in the lymph gland: plasmatocytes, lamellocytes, and crystal cells, which are analogous to vertebrate myeloid cells, yet molecular underpinnings of the lymph gland hemocytes have been less investigated. Here, we use single-cell RNA sequencing to comprehensively analyze heterogeneity of developing hemocytes in the lymph gland, and discover previously undescribed hemocyte types including adipohemocytes, stem-like prohemocytes, and intermediate prohemocytes. Additionally, we identify the developmental trajectory of hemocytes during normal development as well as the emergence of the lamellocyte lineage following active cellular immunity caused by wasp infestation. Finally, we establish similarities and differences between embryonically derived- and larval lymph gland hemocytes. Altogether, our study provides detailed insights into the hemocyte development and cellular immune responses at single-cell resolution.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSingle-cell transcriptome maps of myeloid blood cell lineages in Drosophila-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorBumsik Cho-
dc.contributor.googleauthorSang-Ho Yoon-
dc.contributor.googleauthorDaewon Lee-
dc.contributor.googleauthorFerdinand Koranteng-
dc.contributor.googleauthorSudhir Gopal Tattikota-
dc.contributor.googleauthorNuri Cha-
dc.contributor.googleauthorMingyu Shin-
dc.contributor.googleauthorHobin Do-
dc.contributor.googleauthorYanhui Hu-
dc.contributor.googleauthorSue Young Oh-
dc.contributor.googleauthorDaehan Lee-
dc.contributor.googleauthorA Vipin Menon-
dc.contributor.googleauthorSeok Jun Moon-
dc.contributor.googleauthorNorbert Perrimon-
dc.contributor.googleauthorJin-Wu Nam-
dc.contributor.googleauthorJiwon Shim-
dc.identifier.doi10.1038/s41467-020-18135-y-
dc.contributor.localIdA01358-
dc.relation.journalcodeJ02293-
dc.identifier.eissn2041-1723-
dc.identifier.pmid32900993-
dc.contributor.alternativeNameMoon, Seok Jun-
dc.contributor.affiliatedAuthor문석준-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage4483-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, Vol.11(1) : 4483, 2020-09-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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