15 22

Cited 0 times in

Evaluation of skin phototoxicity of transdermally administered pharmaceuticals in Sprague-Dawley rats

Authors
 Nam Hee Youn  ;  Eun Ji Kim  ;  Jung-Sun Yi  ;  Joo Hwan Kim  ;  Ye-Jin Cho  ;  Ki Taek Nam  ;  Ki Sook Park  ;  Jong Kwon Lee 
Citation
 Laboratory Animal Research, Vol.36(1) : 42, 2020-11 
Journal Title
 Laboratory Animal Research 
ISSN
 1738-6055 
Issue Date
2020-11
Keywords
Histopathology ; In vivo test ; Phototoxicity ; Skin reaction ; Transdermal
Abstract
Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test method to evaluate this has not been established. This study aimed to establish an in vivo phototoxicity test method for transdermally administered drugs. For this, we evaluated the phototoxicity using Sprague-Dawley (SD) rats for transdermal administered drugs and we studied the appropriate UVA dose using 8-methoxypsalen, which is a well-known phototoxic drug. We found that a UVA dose of 15 J/cm2 was dose and time dependent response compared to other UVA doses. We performed the Minimum Erythema Dose (MED) test because UVB can cause skin irritation by itself and selected 0.01 J/cm2 as an appropriate dose of UVB. Using the selected UVA and UVB doses, we performed a phototoxicity study of 6 pharmaceutical drugs, which included phototoxic and non-phototoxic drugs. As a result of the phototoxicity test, 100% accuracy was obtained when compared with previous studies. In addition, we performed histopathology to confirm the new findings. We found that histopathology can be used as an additional indicator of phototoxicity test for transdermally administered drugs.
Files in This Item:
T202005718.pdf Download
DOI
10.1186/s42826-020-00074-w
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181438
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links