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Comparison of Biocompatibility of Calcium Silicate-Based Sealers and Epoxy Resin-Based Sealer on Human Periodontal Ligament Stem Cells

DC FieldValueLanguage
dc.contributor.author김선일-
dc.contributor.author김의성-
dc.contributor.author신수정-
dc.date.accessioned2021-01-19T07:57:46Z-
dc.date.available2021-01-19T07:57:46Z-
dc.date.issued2020-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181394-
dc.description.abstractThe aim of this study was to evaluate the biocompatibility of calcium silicate-based sealers (CeraSeal and EndoSeal TCS) and epoxy resin-based sealer (AH-Plus) in terms of cell viability, inflammatory response, expression of mesenchymal phenotype, osteogenic potential, cell attachment, and morphology, of human periodontal ligament stem cells (hPDLSCs). hPDLSCs were acquired from the premolars (n = 4) of four subjects, whose ages extended from 16 to 24 years of age. Flow cytometry analysis showed stemness of hPDLSCs was maintained in all materials. In cell viability test, AH-Plus showed the lowest cell viability, and CeraSeal showed significantly higher cell viability than others. In ELISA test, AH-Plus showed higher expression of IL-6 and IL-8 than calcium silicate-based sealers. In an osteogenic potential test, AH-Plus showed a lower expression level than other material; however, EndoSeal TCS showed a better expression level than others. All experiments were repeated at least three times per cell line. Scanning electronic microscopy studies showed low degree of cell proliferation on AH-Plus, and high degree of cell proliferation on calcium silicate-based sealers. In this study, calcium silicate-based sealers appear to be more biocompatible and less cytotoxic than epoxy-resin based sealers.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfMATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleComparison of Biocompatibility of Calcium Silicate-Based Sealers and Epoxy Resin-Based Sealer on Human Periodontal Ligament Stem Cells-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Conservative Dentistry (보존과학교실)-
dc.contributor.googleauthorHanseul Oh-
dc.contributor.googleauthorEgan Kim-
dc.contributor.googleauthorSukjoon Lee-
dc.contributor.googleauthorSoyeon Park-
dc.contributor.googleauthorDongzi Chen-
dc.contributor.googleauthorSu-Jung Shin-
dc.contributor.googleauthorEuiseong Kim-
dc.contributor.googleauthorSunil Kim-
dc.identifier.doi10.3390/ma13225242-
dc.contributor.localIdA00556-
dc.contributor.localIdA00833-
dc.contributor.localIdA00833-
dc.contributor.localIdA02117-
dc.contributor.localIdA02117-
dc.relation.journalcodeJ02182-
dc.identifier.eissn1996-1944-
dc.identifier.pmid33233519-
dc.subject.keywordbiocompatibility-
dc.subject.keywordcalcium silicate-based sealer-
dc.subject.keywordcell viability-
dc.subject.keywordepoxy resin-based sealer-
dc.subject.keywordinflammatory response-
dc.subject.keywordperiodontal ligament stem cell-
dc.subject.keywordroot canal treatment-
dc.contributor.alternativeNameKim, Sun Il-
dc.contributor.affiliatedAuthor김선일-
dc.contributor.affiliatedAuthor김의성-
dc.contributor.affiliatedAuthor김의성-
dc.contributor.affiliatedAuthor신수정-
dc.contributor.affiliatedAuthor신수정-
dc.citation.volume13-
dc.citation.number22-
dc.citation.startPage5242-
dc.identifier.bibliographicCitationMATERIALS, Vol.13(22) : 5242, 2020-11-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers

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