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Clinical characteristics and mortality of patients with hematologic malignancies and COVID-19: a systematic review

Authors
 J S Kim  ;  K H Lee  ;  G E Kim  ;  S Kim  ;  J W Yang  ;  H Li  ;  S H Hong  ;  R A Ghayda  ;  A Kronbichler  ;  A Koyanagi  ;  L Jacob  ;  J I Shin  ;  L Smith 
Citation
 EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, Vol.24(22) : 11926-11933, 2020-11 
Journal Title
 EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 
ISSN
 1128-3602 
Issue Date
2020-11
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19 / blood ; COVID-19 / complications* ; COVID-19 / mortality ; COVID-19 / physiopathology ; Child ; Child, Preschool ; Dyspnea / epidemiology ; Dyspnea / physiopathology* ; Female ; Fever / epidemiology ; Fever / physiopathology ; Hematologic Neoplasms / complications* ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell / complications ; Leukocytosis / blood ; Leukocytosis / epidemiology ; Lymphocytosis / blood* ; Lymphocytosis / epidemiology ; Lymphoma, Non-Hodgkin / complications ; Lymphopenia / blood* ; Lymphopenia / epidemiology ; Male ; Middle Aged ; Multiple Myeloma / complications ; Thrombocytopenia / blood* ; Thrombocytopenia / epidemiology ; Young Adult
Abstract
Objective: Hematologic cancer patients with Coronavirus Disease 2019 (COVID-19) tend to have a more serious disease course than observed in the general population. Herein, we comprehensively reviewed existing literature and analyzed clinical characteristics and mortality of patients with hematologic malignancies and COVID-19. Materials and methods: Through searching PubMed until June 03, 2020, we identified 16 relevant case studies (33 cases) from a total of 45 studies that have reported on patients with COVID-19 and hematologic malignancies. We investigated the clinical and laboratory characteristics including type of hematologic malignancies, initial symptoms, laboratory findings, and clinical outcomes. Then, we compared those characteristics and outcomes of patients with hematologic malignancies and COVID-19 to the general population infected with COVID-19. Results: The median age was 66-year-old. Chronic lymphocytic leukemia was the most common type of hematologic malignancy (39.4%). Fever was the most common symptom (75.9%). Most patients had normal leukocyte counts (55.6%), lymphocytosis (45.4%), and normal platelet counts (68.8%). In comparison to patients with COVID-19 without underlying hematologic malignancies, dyspnea was more prevalent (45.0 vs. 24.9%, p=0.025). Leukocytosis (38.9 vs. 9.8%, p=0.001), lymphocytosis (45.4 vs. 8.2%, p=0.001), and thrombocytopenia (31.3 vs. 11.4%, p=0.036) were significantly more prevalent and lymphopenia (18.2 vs. 57.4%, p=0.012) less prevalent in patients with hematologic malignancies. There were no clinical and laboratory characteristics predicting mortality in patients with hematologic malignancies. Mortality was much higher in patients with hematologic malignancies compared to those without this condition (40.0 vs. 3.6%, p<0.001). Conclusions: Co-occurrence of hematologic malignancies and COVID-19 is rare. However, due to the high mortality rate from COVID-19 in this vulnerable population, further investigation on tailored treatment and management is required.
Files in This Item:
T202005513.pdf Download
DOI
10.26355/eurrev_202011_23852
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, Keum Hwa(이금화) ORCID logo https://orcid.org/0000-0002-1511-9587
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181365
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