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Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma

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dc.contributor.author김찬윤-
dc.contributor.author배형원-
dc.contributor.author성공제-
dc.contributor.author이상엽-
dc.contributor.author이택준-
dc.contributor.author최웅락-
dc.date.accessioned2021-01-19T07:52:25Z-
dc.date.available2021-01-19T07:52:25Z-
dc.date.issued2020-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181361-
dc.description.abstractPurpose: The pattern electroretinogram (PERG) is useful to detect retinal ganglion cell (RGC) damage in patients with glaucoma. Optical coherence tomography angiography (OCTA) measures retinal vessel density (VD), which is known to be reduced in glaucoma. There may be correlations between parameters of the PERG and OCTA in open-angle glaucoma (OAG). Methods: In total, 95 eyes of 95 OAG patients and 102 eyes of 102 normal controls were included in this study. N35, P50, and N95 latency along with P50 and N95 amplitude were obtained using the PERG. Retinal VD was measured around the peripapillary and macular area according to the ETDRS grid (concentric circles with diameters of 1, 3, and 6 mm), which is named a center (≤1 mm), an inner (1-3 mm), an outer (3-6 mm), and a full (≤6 mm) area. Pearson correlation analysis was done between parameters, and partial correlation analysis was done after adjusting confounding factors. Results: P50 amplitude, N95 amplitude, and VD of most measured areas were significantly lower in the OAG group compared to the normal group. N95 amplitude showed a statistically significant correlation with parameters of optical coherence tomography and visual field, peripapillary outer and full VD, and macular outer and full VD even after adjusting confounding factors. There was no significant correlation between parameters in the normal group. Conclusions: N95 amplitude was associated with structural and functional change including VD reduction in OAG. Microvascular alterations may be associated with dysfunctional changes of RGC recorded by the PERG in OAG.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJOURNAL OF CLINICAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleRelationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorTaekjune Lee-
dc.contributor.googleauthorDu Ri Seo-
dc.contributor.googleauthorJoo Yeon Kim-
dc.contributor.googleauthorWungrak Choi-
dc.contributor.googleauthorSang Yeop Lee-
dc.contributor.googleauthorJun Mo Lee-
dc.contributor.googleauthorGong Je Seong-
dc.contributor.googleauthorChan Yun Kim-
dc.contributor.googleauthorHyoung Won Bae-
dc.identifier.doi10.3390/jcm9123854-
dc.contributor.localIdA01035-
dc.contributor.localIdA01814-
dc.contributor.localIdA01814-
dc.contributor.localIdA01946-
dc.contributor.localIdA01946-
dc.contributor.localIdA02820-
dc.contributor.localIdA02820-
dc.contributor.localIdA04790-
dc.contributor.localIdA04790-
dc.contributor.localIdA04123-
dc.contributor.localIdA04123-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid33260929-
dc.subject.keywordN95 amplitude-
dc.subject.keywordopen-angle glaucoma-
dc.subject.keywordoptical coherence tomography angiography-
dc.subject.keywordpattern electroretinogram-
dc.contributor.alternativeNameKim, Chan Yun-
dc.contributor.affiliatedAuthor김찬윤-
dc.contributor.affiliatedAuthor배형원-
dc.contributor.affiliatedAuthor배형원-
dc.contributor.affiliatedAuthor성공제-
dc.contributor.affiliatedAuthor성공제-
dc.contributor.affiliatedAuthor이상엽-
dc.contributor.affiliatedAuthor이상엽-
dc.contributor.affiliatedAuthor이택준-
dc.contributor.affiliatedAuthor이택준-
dc.contributor.affiliatedAuthor최웅락-
dc.contributor.affiliatedAuthor최웅락-
dc.citation.volume9-
dc.citation.number12-
dc.citation.startPage3854-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MEDICINE, Vol.9(12) : 3854, 2020-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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