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Repeated Pancreatectomy for Isolated Local Recurrence in the Remnant Pancreas Following Radical Pancreatectomy for Pancreatic Ductal Adenocarcinoma: A Pooled Analysis

DC FieldValueLanguage
dc.contributor.author강창무-
dc.contributor.author이우정-
dc.contributor.author황호경-
dc.date.accessioned2021-01-19T07:47:45Z-
dc.date.available2021-01-19T07:47:45Z-
dc.date.issued2020-12-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181330-
dc.description.abstractThe mainstream treatment for recurrent pancreatic cancer is potent chemotherapy or chemoradiotherapy. However, recent clinical investigations have suggested a potential oncologic role of local resection of recurrent pancreatic cancer. This systemic review with a pooled analysis aimed to assess the potential role of local repeated pancreatectomy with respect to the survival outcomes for patients with recurrent pancreatic ductal adenocarcinoma (PDAC) in the remnant pancreas. The PubMed database was searched, and 15 articles reporting on repeated pancreatectomy for local recurrence of PDAC in the remnant pancreas were identified. The pooled individual data were examined for the clinical outcomes of repeated pancreatectomy for recurrent PDAC. The survival analysis was performed using the Kaplan-Meier method. In the pooled analysis, the mean time interval from initial pancreatectomy to repeated pancreatectomy was 41.3 months (standard deviation (SD), 29.09 months). Completion total pancreatectomy was most commonly performed as repeated pancreatectomy (46 patients, 92.0%), and partial pancreatic resection was performed for only 4 (10.3%) patients. Twenty (40.9%) patients received postoperative chemotherapy following repeated pancreatectomy. The median overall survival was 60 months (95% confidential interval (CI): 45.99-74.01) after repeated pancreatectomy for isolated local recurrence in the remnant pancreas. Overall survival was markedly longer considering the timing of the initial pancreatectomy for pancreatic cancer (median, 107 months (95% CI: 80.37-133.62). The time interval between the initial and subsequent repeated pancreatectomy for pancreatic cancer was not associated with long-term oncologic outcomes (p = 0.254). Repeated pancreatectomy cannot completely replace adjuvant chemotherapy but should be considered for patients with isolated local recurrent PDAC in the remnant pancreas.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJOURNAL OF CLINICAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleRepeated Pancreatectomy for Isolated Local Recurrence in the Remnant Pancreas Following Radical Pancreatectomy for Pancreatic Ductal Adenocarcinoma: A Pooled Analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorMunseok Choi-
dc.contributor.googleauthorNa Won Kim-
dc.contributor.googleauthorHo Kyoung Hwang-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorChang Moo Kang-
dc.identifier.doi10.3390/jcm9123945-
dc.contributor.localIdA00088-
dc.contributor.localIdA02993-
dc.contributor.localIdA02993-
dc.contributor.localIdA04497-
dc.contributor.localIdA04497-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid33291378-
dc.subject.keywordcompletion total pancreatectomy-
dc.subject.keywordpancreatic ductal adenocarcinoma-
dc.subject.keywordpooled analysis-
dc.subject.keywordrecurrent pancreatic cancer-
dc.subject.keywordrepeated pancreatectomy-
dc.subject.keywordsurvival-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.affiliatedAuthor강창무-
dc.contributor.affiliatedAuthor이우정-
dc.contributor.affiliatedAuthor이우정-
dc.contributor.affiliatedAuthor황호경-
dc.contributor.affiliatedAuthor황호경-
dc.citation.volume9-
dc.citation.number12-
dc.citation.startPage3945-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MEDICINE, Vol.9(12) : 3945, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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