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Heart Failure with Preserved Ejection Fraction: the Major Unmet Need in Cardiology

Authors
 Chi Young Shim 
Citation
 KOREAN CIRCULATION JOURNAL, Vol.50(12) : 1051-1061, 2020-12 
Journal Title
 KOREAN CIRCULATION JOURNAL 
ISSN
 1738-5520 
Issue Date
2020-12
Keywords
Diagnosis ; Heart failure with preserved ejection fraction ; Pathophysiology ; Syndrome ; Treatment
Abstract
Heart failure with preserved ejection fraction (HFpEF) has recently been recognized as the single greatest unmet need in cardiovascular medicine. As the population ages and the comorbidity increases, the prevalence of HFpEF increases considerably. Even though there have been large numbers of studies on pathophysiology, diagnosis, and treatment of HFpEF for latest years, there are no current pharmacologic interventions that can reduce mortality. HFpEF is currently understood as a heterogeneous syndrome originated from the interplay of cardiac and extracardiac abnormalities recognized by systemic inflammation, endothelial and coronary microvascular dysfunction, cardiomyocyte dysfunction and skeletal muscle dysfunction. The difficult "jigsaw puzzle" called HFpEF has been filled with some pieces, but it is still not enough to meet clinical needs. Here, we review recent evidences and unsolved problems about HFpEF to improve our understanding of HFpEF. Finally, we hope to accelerate to completion of the problematic "jigsaw puzzle".
Files in This Item:
T202005343.pdf Download
DOI
10.4070/kcj.2020.0338
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181290
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