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Sex-based Approach for the Clinical Impact of the Increased Hemoglobin on Incident AF in the General Population

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dc.contributor.author김인수-
dc.contributor.author김종윤-
dc.contributor.author이병권-
dc.contributor.author정보영-
dc.date.accessioned2020-12-11T08:10:06Z-
dc.date.available2020-12-11T08:10:06Z-
dc.date.issued2020-12-
dc.identifier.issn1738-5520-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180800-
dc.description.abstractBackground and objectives: Although the adverse cardiovascular effect of anemia has been well described, the effect of polycythemia on the incident atrial fibrillation (AF) remain unclear. The objective of this study is to identify the association between increased hemoglobin and incident AF. Methods: This was a retrospective-cohort study with 434,269 subjects who underwent national health examinations from the Korean National Sample Cohort. We estimated the risk of incident AF according to hemoglobin-based four-categories. Results: During 3.9-year of follow-up, polycythemia group showed higher incidences of AF (hazard ratio[HR] with 95% confidence interval[CI], 1.50 [1.28-1.76] and 1.69 [1.13-2.56]; in men and women, respectively) than normal hemoglobin group (each p<0.001). In the normal hemoglobin and polycythemia groups, a 1 g/dL increase in hemoglobin level was associated with increased risks of incident AF (1.12 [1.07-1.17] and 1.18 [1.10-1.26] in men and women, each p<0.001). To investigate the specific hemoglobin concentration related to greater AF incidence, we analyzed the sensitivity/specificity of different hemoglobin levels: ≥16.0 g/dL in men and ≥14.5 g/dL in women showed the highest Youden's index, with c-indices of 0.83 and 0.82, respectively. Kaplan-Meier cumulative-event curves according to these specific hemoglobin levels (≥16.0 g/dL in men and ≥14.5 g/dL in women) also showed consistent results in both sexes (each p<0.05). Conclusions: Even in the Korean general population, increased hemoglobin was significantly associated with higher rate of incident AF. Especially, subjects with hemoglobin levels ≥14.5 g/dL in women and ≥16.0 g/dL among men were associated with increased risk of incident AF.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Korean-
dc.publisherKorean Society of Circulation-
dc.relation.isPartOfKOREAN CIRCULATION JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSex-based Approach for the Clinical Impact of the Increased Hemoglobin on Incident AF in the General Population-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorIn Soo Kim-
dc.contributor.googleauthorByoung Kwon Lee-
dc.contributor.googleauthorPil Sung Yang-
dc.contributor.googleauthorBoyoung Joung-
dc.contributor.googleauthorJong Youn Kim-
dc.identifier.doi10.4070/kcj.2020.0412-
dc.contributor.localIdA00840-
dc.contributor.localIdA00926-
dc.contributor.localIdA02793-
dc.contributor.localIdA03609-
dc.relation.journalcodeJ01952-
dc.identifier.eissn1738-5555-
dc.identifier.pmid33258318-
dc.subject.keywordAtrial fibrillation-
dc.subject.keywordHemoglobins-
dc.subject.keywordPolycythemia-
dc.subject.keywordSex-
dc.contributor.alternativeNameKim, In-Soo-
dc.contributor.affiliatedAuthor김인수-
dc.contributor.affiliatedAuthor김종윤-
dc.contributor.affiliatedAuthor이병권-
dc.contributor.affiliatedAuthor정보영-
dc.citation.volume50-
dc.citation.number12-
dc.citation.startPage1095-
dc.citation.endPage1110-
dc.identifier.bibliographicCitationKOREAN CIRCULATION JOURNAL, Vol.50(12) : 1095-1110, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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