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Urinary bisphenol A, phthalate metabolites, and obesity: do gender and menopausal status matter?

Authors
 Jung-Eun Lim  ;  BongKyoo Choi  ;  Sun Ha Jee 
Citation
 ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, Vol.27(27) : 34300-34310, 2020-09 
Journal Title
 ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 
ISSN
 0944-1344 
Issue Date
2020-09
MeSH
Adult ; Benzhydryl Compounds ; Chromatography, Liquid ; Environmental Pollutants* ; Female ; Humans ; Male ; Obesity ; Phenols ; Phthalic Acids* ; Republic of Korea ; Tandem Mass Spectrometry
Keywords
Bisphenol A ; Menopause ; Obesity ; Observational study ; Phthalate ; Waist circumference
Abstract
Previous studies of urinary bisphenol A (BPA), phthalate metabolites, and obesity risk have shown inconsistent results. Menopausal status is one of the main factors that affect hormone secretion change in women. In this study, we examined whether urinary BPA and phthalate metabolite levels are associated with obesity and whether the associations differ by sex and menopausal status in a sample of Korean adult populations. We recruited participants at three branches (Yeouido, Gangnam, and Gwanghwamun) of the Korea Medical Institute, a nationwide health check-up center, from 2015 to 2016. Urinary BPA level was measured by high-performance liquid chromatography-tandem mass spectrometry (Agilent 6490 Triple Quad LC-MS/MS; Agilent Technologies, CA, USA). Urinary six phthalate metabolites were analyzed with ultra-high-performance liquid chromatography-tandem mass spectrometry (TSQ Quantum Access Mass; Thermo Fisher Scientific, MA, USA). Participants with body mass index ≥ 25 kg/m2 were defined as general obesity group. Men with waist circumference (WC) ≥ 90 cm and women with WC ≥ 85 cm were defined as abdominal obesity group. Age, sex, alcohol intake, smoking, and exercise were considered in multivariate logistic regression models. Among the total of 702 participants, 211 participants were classified into the general obesity group, and 131 participants were classified into the abdominal obesity group. Urinary phthalate metabolite levels were not associated with general and abdominal obesity in men and women. However, in women, urinary BPA concentration was positively associated with abdominal obesity (OR = 1.50, 95% CI 1.00-2.26). Also, the association was stronger in postmenopausal women (OR = 2.23, 1.01-4.92), while it was weak in premenopausal women (OR = 1.31, 0.78-2.20). In this study, urinary BPA concentration was associated with abdominal obesity in women, especially postmenopausal women. Future studies should consider sex and menopausal status when investigating associations between urinary BPA, phthalate metabolites levels, and obesity.
Full Text
https://link.springer.com/article/10.1007%2Fs11356-020-09570-x
DOI
10.1007/s11356-020-09570-x
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Lim, Jung-eun(임정은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180784
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