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Untargeted Metabolomics and Polyamine Profiling in Serum before and after Surgery in Colorectal Cancer Patients

Authors
 Yu Ra Lee  ;  Ki-Yong An  ;  Justin Jeon  ;  Nam Kyu Kim  ;  Ji Won Lee  ;  Jongki Hong  ;  Bong Chul Chung 
Citation
 METABOLITES, Vol.10(12) : E487, 2020-11 
Journal Title
 METABOLITES 
Issue Date
2020-11
Keywords
biomarker ; colorectal cancer ; liquid chromatography-mass spectrometry ; metabolomics ; polyamine ; tumorectomy
Abstract
Colorectal cancer is one of the most prevalent cancers in Korea and globally. In this study, we aimed to characterize the differential serum metabolomic profiles between pre-operative and post-operative patients with colorectal cancer. To investigate the significant metabolites and metabolic pathways associated with colorectal cancer, we analyzed serum samples from 68 patients (aged 20-71, mean 57.57 years). Untargeted and targeted metabolomics profiling in patients with colorectal cancer were performed using liquid chromatography-mass spectrometry. Untargeted analysis identified differences in sphingolipid metabolism, steroid biosynthesis, and arginine and proline metabolism in pre- and post-operative patients with colorectal cancer. We then performed quantitative target profiling of polyamines, synthesized from arginine and proline metabolism, to identify potential polyamines that may serve as effective biomarkers for colorectal cancer. Results indicate a significantly reduced serum concentration of putrescine in post-operative patients compared to pre-operative patients. Our metabolomics approach provided insights into the physiological alterations in patients with colorectal cancer after surgery.
Files in This Item:
T202005228.pdf Download
DOI
10.3390/metabo10120487
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180770
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