Cited 12 times in
Positive Association of Serum Alkaline Phosphatase Level with Severe Knee Osteoarthritis: A Nationwide Population-Based Study
DC Field | Value | Language |
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dc.contributor.author | 박혜민 | - |
dc.contributor.author | 이용제 | - |
dc.contributor.author | 이준혁 | - |
dc.date.accessioned | 2020-12-11T08:04:57Z | - |
dc.date.available | 2020-12-11T08:04:57Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180767 | - |
dc.description.abstract | Serum alkaline phosphatase (ALP), a well-known marker of hepatobiliary and bone disorders, has recently been discovered to be a biochemical marker of cardiometabolic diseases and chronic low-grade inflammation. We aimed to evaluate the association of serum ALP level with knee osteoarthritis in the general population. The study included 3060 men and women aged ≥50 years who participated in the 2009-2011 Korea National Health and Nutrition Examination Survey. The participants were categorized into three groups based on log-transformed serum ALP level as follows: T1 (1.74-2.32), T2 (2.33-2.43), and T3 (2.44-3.01). Their radiographs were evaluated by two well-trained radiologists using the Kellgren-Lawrence (KL) grading system. After excluding those with KL Grade 0, we categorized the remaining participants into two groups, a severe osteoarthritis group (KL Grade 4) and a non-severe osteoarthritis group (KL Grades 1 to 3). The odds ratios (ORs) with 95% confidence intervals (CIs) of severe osteoarthritis according to the tertiles of log-transformed serum ALP levels of patients with osteoarthritis were calculated using a weighted multivariate logistic regression analysis. Compared with T1, the adjusted ORs (95% CIs) for severe osteoarthritis of the T3 serum ALP group was 1.613 (1.087-2.394; p = 0.018) after adjusting for the confounding variables. Conclusively, serum ALP activity was independently and positively associated with severe knee osteoarthritis in middle-aged and older adults. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | DIAGNOSTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Positive Association of Serum Alkaline Phosphatase Level with Severe Knee Osteoarthritis: A Nationwide Population-Based Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Hye-Min Park | - |
dc.contributor.googleauthor | Jun-Hyuk Lee | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.identifier.doi | 10.3390/diagnostics10121016 | - |
dc.contributor.localId | A05789 | - |
dc.contributor.localId | A02982 | - |
dc.contributor.localId | A05837 | - |
dc.relation.journalcode | J03798 | - |
dc.identifier.eissn | 2075-4418 | - |
dc.identifier.pmid | 33261160 | - |
dc.subject.keyword | low-grade inflammation | - |
dc.subject.keyword | serum alkaline phosphatase | - |
dc.subject.keyword | severe knee osteoarthritis | - |
dc.contributor.alternativeName | Park, Hye-Min | - |
dc.contributor.affiliatedAuthor | 박혜민 | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.contributor.affiliatedAuthor | 이준혁 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1016 | - |
dc.identifier.bibliographicCitation | DIAGNOSTICS, Vol.10(12) : 1016, 2020-12 | - |
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