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The incidence rates and risk factors of Parkinson disease in patients with psoriasis: A nationwide population-based cohort study
DC Field | Value | Language |
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dc.contributor.author | 지헌영 | - |
dc.date.accessioned | 2020-12-11T07:54:02Z | - |
dc.date.available | 2020-12-11T07:54:02Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 0190-9622 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180701 | - |
dc.description.abstract | Background: The association between psoriasis and Parkinson disease has not been established. Objective: To determine the incidence rates and risk factors of Parkinson disease in patients with psoriasis. Methods: We conducted a nationwide population-based cohort study. The data from patients with psoriasis (N = 548,327, ≥20 years of age, 53.32% men and 46.68% women) and age- and sex-matched control patients (N = 2,741,635) without psoriasis were analyzed in this study. Results: The incidence rates of Parkinson disease per 1000 person-years were 0.673 and 0.768 in the control and psoriasis groups, respectively. The psoriasis group showed a significantly increased risk of developing Parkinson disease (hazard ratio [HR] 1.091, 95% confidence interval [CI] 1.029-1.115). The risk of Parkinson disease was significantly higher among the psoriasis patients who were not receiving systemic therapy (HR 1.093, 95% CI 1.031-1.159) and lower among the psoriasis patients on systemic therapy (HR 1.04, 95% CI 0.806-1.316). Limitations: The limitations of this study included the retrospective design, patient inclusion solely on the basis of diagnostic codes, and unavailability of data on confounding factors. Conclusion: Systemic anti-inflammatory agents might mitigate the risk of Parkinson disease in psoriasis patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Mosby | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The incidence rates and risk factors of Parkinson disease in patients with psoriasis: A nationwide population-based cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Ji Hyun Lee | - |
dc.contributor.googleauthor | Kyungdo Han | - |
dc.contributor.googleauthor | Heon Yung Gee | - |
dc.identifier.doi | 10.1016/j.jaad.2019.07.012 | - |
dc.contributor.localId | A03971 | - |
dc.relation.journalcode | J01766 | - |
dc.identifier.eissn | 1097-6787 | - |
dc.identifier.pmid | 31302182 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0190962219323679 | - |
dc.subject.keyword | Parkinson disease | - |
dc.subject.keyword | cohort study | - |
dc.subject.keyword | incidence | - |
dc.subject.keyword | population-based | - |
dc.subject.keyword | psoriasis | - |
dc.subject.keyword | risk factor | - |
dc.contributor.alternativeName | Gee, Heon Yung | - |
dc.contributor.affiliatedAuthor | 지헌영 | - |
dc.citation.volume | 83 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1688 | - |
dc.citation.endPage | 1695 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol.83(6) : 1688-1695, 2020-12 | - |
dc.identifier.rimsid | 64433 | - |
dc.type.rims | ART | - |
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