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Intracellular Ca 2+-Mediated AE2 Is Involved in the Vectorial Movement of HaCaT Keratinocyte

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dc.contributor.author신동민-
dc.date.accessioned2020-12-11T07:52:21Z-
dc.date.available2020-12-11T07:52:21Z-
dc.date.issued2020-11-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180692-
dc.description.abstractKeratinocyte migration is initiated toward the wound skin barrier as a crucial process in wound healing. However, the migratory machinery used by keratinocytes is relatively unknown. Histamine signaling, including an increase in the Ca2+ signal, mediated the enhanced protein expression and chloride/bicarbonate exchange activity of anion exchanger AE2 in keratinocytes. In this study, we applied an agarose spot assay to induce a vectorial motion. The vectorial stimulation of the histamine-containing agarose spot enhanced the HaCaT keratinocyte migration, compared to non-directional stimulation. AE2 is associated with the vectorial movement of HaCaT keratinocytes. Enhanced expression of AE2 was mainly associated with an increase in Ca2+ and was abolished by the treatment with the Ca2+ chelating agent BAPTA-AM. These findings revealed that the directionality of Ca2+-exerted stimulation can play a prominent role in facilitating migration through the involvement of AE2 as a migratory machinery in HaCaT keratinocytes.-
dc.description.statementOfResponsibilityopen-
dc.languageINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.publisherINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIntracellular Ca 2+-Mediated AE2 Is Involved in the Vectorial Movement of HaCaT Keratinocyte-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorSoyoung Hwang-
dc.contributor.googleauthorDong Min Shin-
dc.contributor.googleauthorJeong Hee Hong-
dc.identifier.doi10.3390/ijms21228429-
dc.contributor.localIdA02091-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid33182643-
dc.subject.keywordanion exchanger 2-
dc.subject.keywordhistamine-
dc.subject.keywordintracellular Ca2+-
dc.subject.keywordkeratinocyte migration-
dc.contributor.alternativeNameShin, Dong Min-
dc.contributor.affiliatedAuthor신동민-
dc.citation.volume21-
dc.citation.number22-
dc.citation.startPage8429-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(22) : 8429, 2020-11-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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