Cited 9 times in
Intracellular Ca 2+-Mediated AE2 Is Involved in the Vectorial Movement of HaCaT Keratinocyte
DC Field | Value | Language |
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dc.contributor.author | 신동민 | - |
dc.date.accessioned | 2020-12-11T07:52:21Z | - |
dc.date.available | 2020-12-11T07:52:21Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180692 | - |
dc.description.abstract | Keratinocyte migration is initiated toward the wound skin barrier as a crucial process in wound healing. However, the migratory machinery used by keratinocytes is relatively unknown. Histamine signaling, including an increase in the Ca2+ signal, mediated the enhanced protein expression and chloride/bicarbonate exchange activity of anion exchanger AE2 in keratinocytes. In this study, we applied an agarose spot assay to induce a vectorial motion. The vectorial stimulation of the histamine-containing agarose spot enhanced the HaCaT keratinocyte migration, compared to non-directional stimulation. AE2 is associated with the vectorial movement of HaCaT keratinocytes. Enhanced expression of AE2 was mainly associated with an increase in Ca2+ and was abolished by the treatment with the Ca2+ chelating agent BAPTA-AM. These findings revealed that the directionality of Ca2+-exerted stimulation can play a prominent role in facilitating migration through the involvement of AE2 as a migratory machinery in HaCaT keratinocytes. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Intracellular Ca 2+-Mediated AE2 Is Involved in the Vectorial Movement of HaCaT Keratinocyte | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Soyoung Hwang | - |
dc.contributor.googleauthor | Dong Min Shin | - |
dc.contributor.googleauthor | Jeong Hee Hong | - |
dc.identifier.doi | 10.3390/ijms21228429 | - |
dc.contributor.localId | A02091 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 33182643 | - |
dc.subject.keyword | anion exchanger 2 | - |
dc.subject.keyword | histamine | - |
dc.subject.keyword | intracellular Ca2+ | - |
dc.subject.keyword | keratinocyte migration | - |
dc.contributor.alternativeName | Shin, Dong Min | - |
dc.contributor.affiliatedAuthor | 신동민 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 8429 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(22) : 8429, 2020-11 | - |
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