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Comparison of the effectiveness and safety of bioactive glass ceramic to allograft bone for anterior cervical discectomy and fusion with anterior plate fixation

 Hyung Cheol Kim  ;  Jae Keun Oh  ;  Du Su Kim  ;  Jeffrey S Roh  ;  Tae Woo Kim  ;  Seong Bae An  ;  Hyeong Seok Jeon  ;  Dong Ah Shin  ;  Seong Yi  ;  Keung Nyun Kim  ;  Do Heum Yoon  ;  Yoon Ha 
 NEUROSURGICAL REVIEW, Vol.43(5) : 1423-1430, 2020-10 
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Allograft bone ; Anterior cervical discectomy and fusion ; Bioactive glass ceramic cage ; Clinical and radiological outcomes ; Fusion rate
Recently, a bioactive glass ceramic (BGC) has been developed for use as intervertebral cages for anterior cervical discectomy and fusion (ACDF). However, the effectiveness and safety of BGC cages remain to be evaluated. We completed a retrospective comparison of the radiological and clinical outcomes of 36 patients (52 levels) who underwent ACDF with a BGC cage and 35 patients (54 levels) using allograft bone. The following variables were compared between the two groups: the visual analog (VAS) neck and arm pain score and the neck disability index (NDI), measured before surgery and 1 year after; the change in Cobb's angle, between the C2 and C7 vertebrae, the global sagittal angle, and disc height compared from before surgery to 1 year after; and the rate of spinal fusion and cage subsidence at 1 and 2 years after surgery. The VAS and NDI scores were not different between the two groups. Similarly, the spinal fusion rate was not different between the BGC and allograft bone group at 1 year (73% and 87%, respectively; p = 0.07) and 2 years (94% and 91%, respectively; p = 0.54) after surgery. However, the rate of cage subsidence was higher in the allograft bone (43%) than the BGC (19%) group (p = 0.03), as was the rate of instrument-related failure (p = 0.028), with a specifically higher incidence of implant fracture or failure in the allograft bone group (p = 0.025). Overall, our findings indicate that BGC cages provide a feasible and safe alternative to allograft bone for ACDF.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Keung Nyun(김긍년)
Kim, Hyung Cheol(김형철)
Shin, Dong Ah(신동아) ORCID logo https://orcid.org/0000-0002-5225-4083
An, Seong Bae(안성배)
Yoon, Do Heum(윤도흠) ORCID logo https://orcid.org/0000-0003-1452-5724
Yi, Seong(이성)
Jeon, Hyeong Seok(전형석)
Ha, Yoon(하윤)
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