17 27

Cited 0 times in

Maternal total cell-free DNA in preeclampsia with and without intrauterine growth restriction

Authors
 Dong Wook Kwak  ;  Shin Young Kim  ;  Hyun Jin Kim  ;  Ji Hyae Lim  ;  Young-Han Kim  ;  Hyun Mee Ryu 
Citation
 SCIENTIFIC REPORTS, Vol.10(1) : 11848, 2020-12 
Journal Title
 SCIENTIFIC REPORTS 
Issue Date
2020-12
Abstract
Elevation of total cell-free DNA (cfDNA) in patients with preeclampsia is well-known; however, whether this change precedes the onset of symptoms remains inconclusive. Here, we conducted a nested case-control study to determine the elevation of cfDNA levels in women who subsequently developed preeclampsia. Methylated HYP2 (m-HYP2) levels were determined in 68 blood samples collected from women with hypertensive disorders of pregnancy, along with 136 control samples, using real-time quantitative PCR. The measured m-HYP2 levels were converted to multiples of the median (MoM) values for correction of maternal characteristics. The m-HYP2 levels and MoM values in patients with preeclampsia were significantly higher than in controls during the third trimester (P < 0.001, both), whereas those for women who subsequently developed preeclampsia did not differ during the second trimester. However, when patients with preeclampsia were divided based on the onset-time of preeclampsia or 10th percentile birth weight, both values were significantly higher in women who subsequently developed early-onset preeclampsia (P < 0.05, both) and preeclampsia with small-for-gestational-age (SGA) neonate (P < 0.01, both) than controls. These results suggested that total cfDNA levels could be used to predict early-onset preeclampsia or preeclampsia with SGA neonate.
Files in This Item:
T202002864.pdf Download
DOI
10.1038/s41598-020-68842-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180646
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links