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Designer Stem Cells: Genome Engineering and the Next Generation of Cell-Based Therapies

Authors
 Farshid Guilak  ;  Lara Pferdehirt  ;  Alison K Ross  ;  Yun-Rak Choi  ;  KelseyH Collins  ;  Robert J Nims  ;  Dakota B Katz  ;  Molly Klimak  ;  Suzanne Tabbaa  ;  Christine T N Pham 
Citation
 JOURNAL OF ORTHOPAEDIC RESEARCH, Vol.37(6) : 1287-1293, 2019-06 
Journal Title
JOURNAL OF ORTHOPAEDIC RESEARCH
ISSN
 0736-0266 
Issue Date
2019-06
MeSH
Animals ; Epigenesis, Genetic ; Gene Editing ; Genetic Engineering / methods* ; Humans ; Orthopedics ; Stem Cell Transplantation / methods* ; Tissue Engineering
Keywords
CRISPR-Cas9 ; MSC ; iPSC ; regenerative medicine ; synthetic biology
Abstract
Stem cells provide tremendous promise for the development of new therapeutic approaches for musculoskeletal conditions. In addition to their multipotency, certain types of stem cells exhibit immunomodulatory effects that can mitigate inflammation and enhance tissue repair. However, the translation of stem cell therapies to clinical practice has proven difficult due to challenges in intradonor and interdonor variability, engraftment, variability in recipient microenvironment and patient indications, and limited therapeutic biological activity. In this regard, the success of stem cell-based therapies may benefit from cellular engineering approaches to enhance factors such as purification, homing and cell survival, trophic effects, or immunomodulatory signaling. By combining recent advances in gene editing, synthetic biology, and tissue engineering, the potential exists to create new classes of "designer" cells that have prescribed cell-surface molecules and receptors as well as synthetic gene circuits that provide for autoregulated drug delivery or enhanced tissue repair.
Files in This Item:
T999201961.pdf Download
DOI
10.1002/jor.24304
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Yun Rak(최윤락)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180634
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