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Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation

 Jihee Kim  ;  Jemin Kim  ;  Young In Lee  ;  Abdurrahman Almurayshid  ;  Jin Young Jung  ;  Ju Hee Lee 
 JOURNAL OF COSMETIC DERMATOLOGY, Vol.19(10) : 2576-2582, 2020-10 
Journal Title
Issue Date
QS Nd:YAG laser ; air pollution ; antioxidant ; lentigo ; vitamin C
Background: Extrinsic skin aging caused by atmospheric pollutants is associated with a sustained inflammatory response which is a significant risk factor for lentigines and melasma.

Aims: The aim of this study was to evaluate the efficacy of topical application of combination formulation of vitamin C, vitamin E, and ferulic acid as an adjuvant to Q-switched Nd:YAG (QSNY) lasers treatment in individuals with lentigines and melasma.

Methods: A single blinded, prospective, randomized split-face trial was conducted. Eighteen men and women between 26 and 53 years old were treated with a combination antioxidant serum on one randomized side of their face immediately after QSNY laser and twice daily for 2 weeks. Patients were evaluated using digital photography and spectrometry to assess the melanin index and erythema index. Melasma severity score and global improvement scores also were assessed.

Results: The treated side of the face exhibited a significantly greater reduction in the melanin index. There was no significant difference in post-treatment erythema. More clinical improvement was observed on the treated side compared with the untreated side.

Conclusions: Our study suggests that topical application of a combination vitamins C, E, and ferulic acid antioxidant formula may be effective as an adjuvant option in QSNY lasers.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jemin(김제민) ORCID logo https://orcid.org/0000-0001-6628-3507
Kim, Jihee(김지희) ORCID logo https://orcid.org/0000-0002-0047-5941
Lee, Young In(이영인) ORCID logo https://orcid.org/0000-0001-6831-7379
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
Jung, Jin Young(정진영)
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