Trifecta Outcomes of Partial Nephrectomy in Patients Over 75 Years Old: Analysis of the REnal SURGery in Elderly (RESURGE) Group
Authors
Ahmet Bindayi ; Riccardo Autorino ; Umberto Capitanio ; Nicola Pavan ; Maria Carmen Mir ; Alessandro Antonelli ; Toshio Takagi ; Riccardo Bertolo ; Tobias Maurer ; Koon Ho Rha ; Jean Alexandre Long ; Bo Yang ; Luigi Schips ; Estevão Lima ; Alberto Breda ; Estefania Linares ; Antonio Celia ; Cosimo De Nunzio ; Ryan Dobbs ; Sunil Patel ; Zachary Hamilton ; Andrew Tracey ; Alessandro Larcher ; Carlo Trombetta ; Carlotta Palumbo ; Kazunari Tanabe ; Thomas Amiel ; Ali Raheem ; Gaelle Fiard ; Chao Zhang ; Roberto Castellucci ; Joan Palou ; Stephen Ryan ; Simone Crivellaro ; Francesco Montorsi ; Francesco Porpiglia ; Ithaar H Derweesh
Citation
EUROPEAN UROLOGY FOCUS, Vol.6(5) : 982-990, 2020-09
Background: Partial nephrectomy (PN) in elderly patients is underutilized with concerns regarding risk of complications and potential for poor outcomes.
Objective: To evaluate quality and functional outcomes of PN in patients >75 yr using trifecta as a composite outcome of surgical quality.
Design, setting, and participants: Multicenter retrospective analysis of 653 patients aged >75 yr who underwent PN (REnal SURGery in Elderly [RESURGE] Group).
Intervention: PN.
Outcome measurements and statistical analysis: Primary outcome was achievement of trifecta (negative margin, no major [Clavien ≥3] urological complications, and ≥90% estimated glomerular filtration rate [eGFR] recovery). Secondary outcomes included chronic kidney disease (CKD) stage III and CKD upstaging. Multivariable analysis (MVA) was used to assess variables for achieving trifecta and functional outcomes. Kaplan-Meier survival analysis (KMA) was used to calculate renal functional outcomes.
Results and limitations: We analyzed 653 patients (mean age 78.4 yr, median follow-up 33 mo; 382 open, 157 laparoscopic, and 114 robotic). Trifecta rate was 40.4% (n=264). Trifecta patients had less transfusion (p<0.001), lower intraoperative (5.3% vs 27%, p<0.001) and postoperative (25.4% vs 37.8%, p=0.001) complications, shorter hospital stay (p=0.045), and lower ΔeGFR (p <0.001). MVA for predictive factors for trifecta revealed decreasing RENAL nephrometry score (odds ratio [OR] 1.26, 95% confidence interval 1.07-1.51, p=0.007) as being associated with increased likelihood to achieve trifecta. Achievement of trifecta was associated with decreased risk of CKD upstaging (OR 0.47, 95% confidence interval 0.32-0.62, p<0.001). KMA showed that trifecta patients had improved 5-yr freedom from CKD stage 3 (93.5% vs 57.7%, p<0.001) and CKD upstaging (84.3% vs 8.2%, p<0.001). Limitations include retrospective design.
Conclusions: PN in elderly patients can be performed with acceptable quality outcomes. Trifecta was associated with decreased tumor complexity and improved functional preservation.
Patient summary: We looked at quality outcomes after partial nephrectomy in elderly patients. Acceptable quality outcomes were achieved, measured by a composite outcome called trifecta, whose achievement was associated with improved kidney functional preservation.