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Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review

 Sojung Yoon  ;  Han Li  ;  Keum Hwa Lee  ;  Sung Hwi Hong  ;  Dohoon Kim  ;  Hyunjoon Im  ;  Woongchan Rah  ;  Eunseol Kim  ;  Seungyeon Cha  ;  Jinho Yang  ;  Andreas Kronbichler  ;  Daniela Kresse  ;  Ai Koyanagi  ;  Louis Jacob  ;  Ramy Abou Ghayda  ;  Jae Il Shin  ;  Lee Smith 
 MEDICINA-LITHUANIA, Vol.56(9) : 474, 2020-09 
Journal Title
Issue Date
Adolescent ; Betacoronavirus* ; Child ; Child, Preschool ; Coronavirus Infections / diagnosis* ; Coronavirus Infections / prevention & control ; Coronavirus Infections / transmission ; Female ; Humans ; Lung / diagnostic imaging* ; Male ; Pandemics / prevention & control ; Pneumonia, Viral / diagnosis* ; Pneumonia, Viral / prevention & control ; Pneumonia, Viral / transmission ; Tomography, X-Ray Computed / methods*
SARS-CoV-2 ; asymptomatic ; characteristics ; child ; coronavirus disease 2019 (COVID-19) ; infant ; novel coronavirus 2019 ; radiography
Background and objectives: Characterization of pediatric coronavirus disease 2019 (COVID-19) is necessary to control the pandemic, as asymptomatic or mildly infected children may act as carriers. To date, there are limited reports describing differences in clinical, laboratory, and radiological characteristics between asymptomatic and symptomatic infection, and between younger and older pediatric patients. The objective of this study is to compare characteristics among: (1) asymptomatic versus symptomatic and (2) less than 10 versus greater or equal to 10 years old pediatric COVID-19 patients. Materials and Methods: We searched for all terms related to pediatric COVID-19 in electronic databases (Embase, Medline, PubMed, and Web of Science) for articles from January 2020. This protocol followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Results: Eligible study designs included case reports and series, while we excluded comments/letters, reviews, and literature not written in English. Initially, 817 articles were identified. Forty-three articles encompassing 158 confirmed pediatric COVID-19 cases were included in the final analyses. Lymphocytosis and high CRP were associated with symptomatic infection. Abnormal chest CT more accurately detected asymptomatic COVID-19 in older patients than in younger ones, but clinical characteristics were similar between older and younger patients. Conclusions: Chest CT scan findings are untrustworthy in younger children with COVID-19 as compared with clinical findings, or significant differences in findings between asymptomatic to symptomatic children. Further studies evaluating pediatric COVID-19 could contribute to potential therapeutic interventions and preventive strategies to limit spreading.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, Keum Hwa(이금화) ORCID logo https://orcid.org/0000-0002-1511-9587
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