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Electrical antimicrobial susceptibility testing based on aptamer-functionalized capacitance sensor array for clinical isolates

DC FieldValueLanguage
dc.contributor.author박인호-
dc.contributor.author신전수-
dc.contributor.author용동은-
dc.date.accessioned2020-12-01T17:36:18Z-
dc.date.available2020-12-01T17:36:18Z-
dc.date.issued2020-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180349-
dc.description.abstractTo prescribe effective antibiotics to patients with bacterial infections in a timely manner and to avoid the misuse of antibiotics, a rapid antimicrobial susceptibility test (AST) is essential. However, conventional AST methods require more than 16 h to provide results; thus, we developed an electrical AST (e-AST) system, which provides results within 6 h. The proposed e-AST is based on an array of 60 aptamer-functionalized capacitance sensors that are comparable to currently available AST panels and a pattern-matching algorithm. The performance of the e-AST was evaluated in comparison with that of broth microdilution as the reference test for clinical strains isolated from septic patients. A total of 4,554 tests using e-AST showed a categorical agreement of 97% with a minor error of 2.2%, major error of 0.38%, and very major error of 0.38%. We expect that the proposed e-AST could potentially aid antimicrobial stewardship efforts and lead to improved patient outcomes.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleElectrical antimicrobial susceptibility testing based on aptamer-functionalized capacitance sensor array for clinical isolates-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorKyo-Seok Lee-
dc.contributor.googleauthorSun-Mi Lee-
dc.contributor.googleauthorJeseung Oh-
dc.contributor.googleauthorIn Ho Park-
dc.contributor.googleauthorJun Ho Song-
dc.contributor.googleauthorMyeonggil Han-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorKook Jin Lim-
dc.contributor.googleauthorJeon-Soo Shin-
dc.contributor.googleauthorKyung-Hwa Yoo-
dc.identifier.doi10.1038/s41598-020-70459-3-
dc.contributor.localIdA01631-
dc.contributor.localIdA02144-
dc.contributor.localIdA02144-
dc.contributor.localIdA02423-
dc.contributor.localIdA02423-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid32792573-
dc.contributor.alternativeNamePark, Inho-
dc.contributor.affiliatedAuthor박인호-
dc.contributor.affiliatedAuthor신전수-
dc.contributor.affiliatedAuthor신전수-
dc.contributor.affiliatedAuthor용동은-
dc.contributor.affiliatedAuthor용동은-
dc.citation.volume10-
dc.citation.number1-
dc.citation.startPage13709-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.10(1) : 13709, 2020-08-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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