Cited 15 times in
Electrical antimicrobial susceptibility testing based on aptamer-functionalized capacitance sensor array for clinical isolates
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박인호 | - |
dc.contributor.author | 신전수 | - |
dc.contributor.author | 용동은 | - |
dc.date.accessioned | 2020-12-01T17:36:18Z | - |
dc.date.available | 2020-12-01T17:36:18Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180349 | - |
dc.description.abstract | To prescribe effective antibiotics to patients with bacterial infections in a timely manner and to avoid the misuse of antibiotics, a rapid antimicrobial susceptibility test (AST) is essential. However, conventional AST methods require more than 16 h to provide results; thus, we developed an electrical AST (e-AST) system, which provides results within 6 h. The proposed e-AST is based on an array of 60 aptamer-functionalized capacitance sensors that are comparable to currently available AST panels and a pattern-matching algorithm. The performance of the e-AST was evaluated in comparison with that of broth microdilution as the reference test for clinical strains isolated from septic patients. A total of 4,554 tests using e-AST showed a categorical agreement of 97% with a minor error of 2.2%, major error of 0.38%, and very major error of 0.38%. We expect that the proposed e-AST could potentially aid antimicrobial stewardship efforts and lead to improved patient outcomes. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Electrical antimicrobial susceptibility testing based on aptamer-functionalized capacitance sensor array for clinical isolates | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Kyo-Seok Lee | - |
dc.contributor.googleauthor | Sun-Mi Lee | - |
dc.contributor.googleauthor | Jeseung Oh | - |
dc.contributor.googleauthor | In Ho Park | - |
dc.contributor.googleauthor | Jun Ho Song | - |
dc.contributor.googleauthor | Myeonggil Han | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Kook Jin Lim | - |
dc.contributor.googleauthor | Jeon-Soo Shin | - |
dc.contributor.googleauthor | Kyung-Hwa Yoo | - |
dc.identifier.doi | 10.1038/s41598-020-70459-3 | - |
dc.contributor.localId | A01631 | - |
dc.contributor.localId | A02144 | - |
dc.contributor.localId | A02423 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 32792573 | - |
dc.contributor.alternativeName | Park, Inho | - |
dc.contributor.affiliatedAuthor | 박인호 | - |
dc.contributor.affiliatedAuthor | 신전수 | - |
dc.contributor.affiliatedAuthor | 용동은 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 13709 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.10(1) : 13709, 2020-08 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.