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A retrospective cytohistological correlation of fine-needle aspiration cytology with classification by the Milan System for Reporting Salivary Gland Cytopathology

Authors
 Ji Hyun Park  ;  Yoon Jin Cha  ;  Ja Yeong Seo  ;  Jae Yol Lim  ;  Soon Won Hong 
Citation
 JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, Vol.54(5) : 419-425, 2020-09 
Journal Title
 JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE 
ISSN
 2383-7837 
Issue Date
2020-09
Keywords
Fine-needle aspiration ; Risk of malignancy ; Salivary gland ; The Milan System for Reporting Salivary Gland Cytopathology
Abstract
Background: Before publication of the new classification system named the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) in 2018, there was no standard classification for salivary gland lesions obtained by fine-needle aspiration (FNA). We therefore aimed to evaluate the diagnostic utility of this system by retrospectively reviewing FNA samples using the MSRSGC and to determine their risk of developing into neoplasms and becoming malignant. Methods: Retrospective slide review and classification of salivary gland FNAs obtained over a 6-year period (2013-2018) at a single center were performed by two pathologists. The risks of neoplasm and malignancy for each category also were calculated. Results: This study surveyed 374 FNAs (371 patients) performed over a six-year period and selected 148 cases that included documented surgical follow-up (39.6%). Among the surgically treated cases, the distributions of FNA categories were as follows: non-diagnostic (ND; 16.9%), non-neoplastic (NN; 2.7%), atypia of undetermined significance (AUS; 3.4%), benign (BN; 54.7%), salivary gland neoplasm of uncertain malignant potential (SUMP; 10.1%), suspicious for malignancy (SM; 6.8%), and malignant (M; 5.4%). The risk of malignancy (ROM) was 24.0% for ND, 0% for NN, 40.0% for AUS, 2.5% for BN, 46.7% for SUMP, 100% for SM, and 87.5% for M. The overall diagnostic accuracy was 95.9% (142/148 cases). Conclusions: The newly proposed MSRSGC appears to be a reliable system for classification of salivary gland lesions according to the associated ROM.
Files in This Item:
T202004595.pdf Download
DOI
10.4132/jptm.2020.06.09
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Seo, Jayeong(서자영) ORCID logo https://orcid.org/0000-0003-4859-3864
Lim, Jae Yol(임재열) ORCID logo https://orcid.org/0000-0002-9757-6414
Cha, Yoon Jin(차윤진) ORCID logo https://orcid.org/0000-0002-5967-4064
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180323
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