복강경하 전자궁절제술의 예방적 항생제로 사용한 Cefotetan과 Cefotiam의 효과 비교

Abstract

Objectives: The purpose of this study was to compare the efficacy of 1-g doses of intravenous cefotetan with that of 1-g doses of intravenous cefotiam in preventing surgical site infections after laparoscopic hysterectomy.

Methods: We performed a retrospective review of 98 women who underwent laparoscopic hysterectomy for leiomyoma or adenomyosis

Results: Among 98 patients, cefotetan was used for 54 patients while cefotiam for 44 patients as prophylactic antibiotics. The demographic and surgical variables such as pre-, post-operative hemoglobin level, estimated blood loss during the operation, transfusion, operation time, uterus weight were not statistically different between the two groups. The post-operative white blood cell (WBC) count was significantly higher in cefotiam group (p=0.047). However, the difference and the ratio of preand post-operative WBC count in the two groups were not statistically significant. The postoperative vaginal bleeding and vaginal cuff infection event were fewer for cefotetan group than those for cefotiam group (p=0.074).

Conclusion: The use of prophylactic cefotetan resulted in lower vaginal bleeding or vaginal cuff infection rates after laparoscopic hysterectomy compared with cefotiam.