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Impact of idiopathic pulmonary fibrosis on recurrence after surgical treatment for stage I-III non-small cell lung cancer

Authors
 Myung Jin Song  ;  Dae Jun Kim  ;  Hyo Chae Paik  ;  Sukki Cho  ;  Kwhanmien Kim  ;  Sanghoon Jheon  ;  Sang Hoon Lee  ;  Jong Sun Park 
Citation
 PLOS ONE, Vol.15(6) : e0235126, 2020-06 
Journal Title
 PLOS ONE 
Issue Date
2020-06
MeSH
Aged ; Carcinoma, Non-Small-Cell Lung / pathology ; Carcinoma, Non-Small-Cell Lung / surgery* ; Disease-Free Survival ; Female ; Humans ; Idiopathic Pulmonary Fibrosis / epidemiology* ; Lung Neoplasms / pathology ; Lung Neoplasms / surgery* ; Male ; Middle Aged ; Neoplasm Recurrence, Local* ; Republic of Korea ; Retrospective Studies ; Risk Factors ; Tertiary Care Centers
Abstract
Background: Idiopathic pulmonary fibrosis (IPF) is an independent risk factor for lung cancer (LC) development; however, its effect on recurrence after curative surgery remains unclear. Objectives: This study aimed to determine the impact of IPF on recurrence-free survival following curative surgical resection of stage I-III non-small cell lung cancer (NSCLC) and investigate the effects of patient and surgical factors on the risk of recurrence. Methods: We reviewed retrospectively collected data of patients with surgically resected stage I-III NSCLC from two tertiary care hospitals in South Korea. By propensity score matching, patients with IPF (LC with IPF) were matched to those without IPF (LC without IPF). Results: In total, 3416 patients underwent surgical resection, and 96 were diagnosed with underlying IPF. In the LC with IPF group, 89.6% patients were men, and the average age was 69.7 years. Sublobar resection was performed more frequently in the LC with IPF group than in the LC without IPF group, while the rate of mediastinal lymph node dissection and dissected node number were lower in the former group. The 5-year recurrence-free survival rate was significantly lower in the LC with IPF group (49.2%) than in the LC without IPF group (69.1%; P<0.001). Multivariable Cox regression analysis revealed that IPF and postoperative stage III were independent risk factors for recurrence. Conclusions: IPF may increase the risk of recurrence after curative surgical treatment for NSCLC. Close surveillance for recurrence is mandatory for patients with underlying IPF.
Files in This Item:
T202004555.pdf Download
DOI
10.1371/journal.pone.0235126
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Paik, Hyo Chae(백효채) ORCID logo https://orcid.org/0000-0001-9309-8235
Lee, Sang Hoon(이상훈) ORCID logo https://orcid.org/0000-0002-7706-5318
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180286
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