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Impact of Oncotype DX Recurrence Score on the Patterns of Locoregional Recurrence in Breast Cancer (Korean Radiation Oncology Group 19-06)

Authors
 Kyubo Kim  ;  Jinhong Jung  ;  Kyung Hwan Shin  ;  Jin Ho Kim  ;  Ji Hyun Chang  ;  Su Ssan Kim  ;  Haeyoung Kim  ;  Won Park  ;  Yong Bae Kim  ;  Jee Suk Chang 
Citation
 JOURNAL OF BREAST CANCER, Vol.23(3) : 314-319, 2020-06 
Journal Title
 JOURNAL OF BREAST CANCER 
ISSN
 1738-6756 
Issue Date
2020-06
Keywords
Breast neoplasm ; Local neoplasm recurrence ; Radiotherapy
Abstract
The current study evaluated the impact of the Oncotype DX recurrence score (RS) on the patterns of locoregional recurrence (LRR) in node-negative, hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer. Totally, 339 patients from 4 institutions were enrolled and analyzed retrospectively. All patients underwent breast-conserving surgery followed by whole-breast irradiation; only 2 patients received regional nodal irradiation (RNI). The RS was < 11 in 55 patients, 11-25 in 241, and > 25 in 43. Sixty-two patients received adjuvant chemotherapy. All patients except 4 received hormonal therapy. During a 62-month median follow-up, local recurrence was observed in 1 patient; regional recurrence, 3; and distant metastasis, 7. All LRRs were observed among patients with a RS > 25, resulting in a 5-year LRR rate of 7.3% in this subgroup. Regional recurrences developed in patients did not receive RNI initially. Thus, RNI might be effective for patients with a high RS.
Files in This Item:
T202004358.pdf Download
DOI
10.4048/jbc.2020.23.e36
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0001-7573-6862
Chang, Jee Suk(장지석) ORCID logo https://orcid.org/0000-0001-7685-3382
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180229
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