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Determination of Serotonin Concentration in Single Human Platelets through Single-Entity Electrochemistry

Authors
 Jungeun Lee  ;  Yeji Kang  ;  Jinho Chang  ;  Jaewoo Song  ;  Byung-Kwon Kim 
Citation
 ACS SENSORS, Vol.5(7) : 1943-1948, 2020-07 
Journal Title
 ACS SENSORS 
ISSN
 2379-3694 
Issue Date
2020-07
Keywords
serotonin biosensor ; platelet serotonin ; human platelet detection ; ultramicroelectrode ; single-entity electrochemistry
Abstract
This research introduces a method to directly detect serotonin in a single platelet through single-entity electrochemistry. Platelets isolated from human blood were analyzed by cyclic voltammetry and current–time measurements. When a single platelet collides with an ultramicroelectrode, serotonin inside the platelet is oxidized at the electrode surface, and an anodic current peak is consequently observed during measurement. The concentration of serotonin can be determined by integrating this peak current. In addition, this method can be used to determine the platelet concentration. Analysis of the collision frequency of platelets can provide information about the platelet concentration in the blood. As a result, platelet levels and serotonin concentrations in single platelets can be measured quickly and easily.
Full Text
https://pubs.acs.org/doi/10.1021/acssensors.0c00267
DOI
10.1021/acssensors.0c00267
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180209
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