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Hierarchical Cluster Analysis of Peripapillary Retinal Nerve Fiber Layer Damage and Macular Ganglion Cell Loss in Open Angle Glaucoma

DC FieldValueLanguage
dc.contributor.author김찬윤-
dc.contributor.author배형원-
dc.contributor.author성공제-
dc.contributor.author이광현-
dc.contributor.author이상엽-
dc.date.accessioned2020-12-01T17:12:38Z-
dc.date.available2020-12-01T17:12:38Z-
dc.date.issued2020-02-
dc.identifier.issn1011-8942-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180171-
dc.description.abstractPurpose: To categorize the structural progression pattern of glaucoma, as detected by optical coherence tomography guided progression analysis, with respect to the peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL). Methods: One hundred sixty-four eyes with primary open-angle glaucoma were studied. The structural progression pattern evaluated by optical coherence tomography guided progression analysis was classified using hierarchical cluster analysis. The clinical parameters, patterns of structural progression, and visual field (VF) changes were compared among the groups. Results: Three groups were included: stable, progressive peripapillary RNFL thinning without macular GCIPL involvement, and progressive thinning of both the peripapillary RNFL and macular GCIPL. The third group, those with progressive peripapillary RNFL and macular GCIPL thinning, showed more progressive peripapillary RNFL thinning in the inferotemporal area and VF progression in the parafoveal area. Conversely, the 12 and 6 o'clock areas were the most common locations of progressive peripapillary RNFL thinning in the group without macular GCIPL involvement. Conclusions: Structural progression patterns of glaucoma can be categorized into three groups. The location of progressive peripapillary RNFL thinning is associated with progressive macular GCIPL thinning and pattern of VF changes in the affected area. Our results indicate that the use of only macular GCIPL analysis is inadequate for analyzing the structural progression of glaucoma.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKJO-
dc.relation.isPartOfKorean Journal of Ophthalmology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHierarchical Cluster Analysis of Peripapillary Retinal Nerve Fiber Layer Damage and Macular Ganglion Cell Loss in Open Angle Glaucoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorKwanghyun Lee-
dc.contributor.googleauthorHyoung Won Bae-
dc.contributor.googleauthorSang Yeop Lee-
dc.contributor.googleauthorGong Je Seong-
dc.contributor.googleauthorChan Yun Kim-
dc.identifier.doi10.3341/kjo.2019.0112-
dc.contributor.localIdA01035-
dc.contributor.localIdA01814-
dc.contributor.localIdA01814-
dc.contributor.localIdA01946-
dc.contributor.localIdA01946-
dc.contributor.localIdA04994-
dc.contributor.localIdA04994-
dc.contributor.localIdA02820-
dc.contributor.localIdA02820-
dc.relation.journalcodeJ02931-
dc.identifier.eissn2092-9382-
dc.identifier.pmid32037750-
dc.subject.keywordGlaucoma-
dc.subject.keywordMachine learning-
dc.subject.keywordOpen angle-
dc.subject.keywordOptical coherence tomography-
dc.contributor.alternativeNameKim, Chan Yun-
dc.contributor.affiliatedAuthor김찬윤-
dc.contributor.affiliatedAuthor배형원-
dc.contributor.affiliatedAuthor배형원-
dc.contributor.affiliatedAuthor성공제-
dc.contributor.affiliatedAuthor성공제-
dc.contributor.affiliatedAuthor이광현-
dc.contributor.affiliatedAuthor이광현-
dc.contributor.affiliatedAuthor이상엽-
dc.contributor.affiliatedAuthor이상엽-
dc.citation.volume34-
dc.citation.number1-
dc.citation.startPage56-
dc.citation.endPage66-
dc.identifier.bibliographicCitationKorean Journal of Ophthalmology, Vol.34(1) : 56-66, 2020-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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