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Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent

DC Field Value Language
dc.contributor.author박수연-
dc.contributor.author손명현-
dc.contributor.author윤호근-
dc.contributor.author홍정연-
dc.date.accessioned2020-12-01T16:56:39Z-
dc.date.available2020-12-01T16:56:39Z-
dc.date.issued2020-08-
dc.identifier.issn1359-7345-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180057-
dc.description.abstract(E)-3-(3-(4-((3-Carbamoylbenzyl)oxy)-3-iodo-5-methoxyphenyl) acryloyl)benzamide (A6) was found to be a potent p300 inhibitor (IC50 = 870 nM) showing a similar binding mode to that of acetyl-CoA, a p300 substrate, and effective anti-fibrotic activity in both TGF-β1-stimulated lung fibroblast cells and bleomycin-induced in vivo lung fibrosis mice.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherRoyal Society of Chemistry-
dc.relation.isPartOfCHEMICAL COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleField-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.googleauthorSoo-Yeon Hwang-
dc.contributor.googleauthorSoo-Yeon Park-
dc.contributor.googleauthorJung Yeon Hong-
dc.contributor.googleauthorSoo Yeon Lee-
dc.contributor.googleauthorJae-Ho Shin-
dc.contributor.googleauthorYounghwa Na-
dc.contributor.googleauthorMyung Hyun Sohn-
dc.contributor.googleauthorHo-Geun Yoon-
dc.contributor.googleauthorYoungjoo Kwon-
dc.identifier.doi10.1039/d0cc03553j-
dc.contributor.localIdA01534-
dc.contributor.localIdA01967-
dc.contributor.localIdA02625-
dc.contributor.localIdA04431-
dc.relation.journalcodeJ00511-
dc.identifier.eissn1364-548X-
dc.identifier.pmid32701101-
dc.identifier.urlhttps://pubs.rsc.org/en/content/articlelanding/2020/CC/D0CC03553J#!divAbstract-
dc.contributor.alternativeNamePark, Soo Yeon-
dc.contributor.affiliatedAuthor박수연-
dc.contributor.affiliatedAuthor손명현-
dc.contributor.affiliatedAuthor윤호근-
dc.contributor.affiliatedAuthor홍정연-
dc.citation.volume56-
dc.citation.number68-
dc.citation.startPage9795-
dc.citation.endPage9798-
dc.identifier.bibliographicCitationCHEMICAL COMMUNICATIONS, Vol.56(68) : 9795-9798, 2020-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
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