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Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent

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dc.contributor.authorHwang, Soo-Yeon-
dc.contributor.authorPark, Soo-Yeon-
dc.contributor.authorHong, Jung Yeon-
dc.contributor.authorLee, Soo Yeon-
dc.contributor.authorShin, Jae-Ho-
dc.contributor.authorNa, Younghwa-
dc.contributor.authorSohn, Myung Hyun-
dc.contributor.authorYoon, Ho-Geun-
dc.contributor.authorKwon, Youngjoo-
dc.date.accessioned2020-12-01T16:56:39Z-
dc.date.available2020-12-01T16:56:39Z-
dc.date.created2021-03-18-
dc.date.issued2020-09-
dc.identifier.issn1359-7345-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180057-
dc.description.abstract(E)-3-(3-(4-((3-Carbamoylbenzyl)oxy)-3-iodo-5-methoxyphenyl) acryloyl)benzamide (A6) was found to be a potent p300 inhibitor (IC50= 870 nM) showing a similar binding mode to that of acetyl-CoA, a p300 substrate, and effective anti-fibrotic activity in both TGF-beta 1-stimulated lung fibroblast cells and bleomycin-inducedin vivolung fibrosis mice.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherRoyal Society of Chemistry-
dc.relation.isPartOfCHEMICAL COMMUNICATIONS-
dc.relation.isPartOfCHEMICAL COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleField-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.googleauthorHwang, Soo-Yeon-
dc.contributor.googleauthorPark, Soo-Yeon-
dc.contributor.googleauthorHong, Jung Yeon-
dc.contributor.googleauthorLee, Soo Yeon-
dc.contributor.googleauthorShin, Jae-Ho-
dc.contributor.googleauthorNa, Younghwa-
dc.contributor.googleauthorSohn, Myung Hyun-
dc.contributor.googleauthorYoon, Ho-Geun-
dc.contributor.googleauthorKwon, Youngjoo-
dc.identifier.doi10.1039/d0cc03553j-
dc.relation.journalcodeJ00511-
dc.identifier.eissn1364-548X-
dc.contributor.alternativeNamePark, Soo Yeon-
dc.contributor.affiliatedAuthorPark, Soo-Yeon-
dc.contributor.affiliatedAuthorHong, Jung Yeon-
dc.contributor.affiliatedAuthorSohn, Myung Hyun-
dc.contributor.affiliatedAuthorYoon, Ho-Geun-
dc.identifier.scopusid2-s2.0-85090076278-
dc.identifier.wosid000562378500006-
dc.citation.volume56-
dc.citation.number68-
dc.citation.startPage9795-
dc.citation.endPage9798-
dc.identifier.bibliographicCitationCHEMICAL COMMUNICATIONS, Vol.56(68) : 9795-9798, 2020-09-
dc.identifier.rimsid68870-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.journalClass1-
dc.subject.keywordPlusBETA-
dc.subject.keywordPlusACETYLATION-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusFIBROSIS-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
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