14 17

Cited 0 times in

Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea

Authors
 Min Hyuk Choi  ;  Hyunmin Ahn  ;  Han Seok Ryu  ;  Byung-Jun Kim  ;  Joonyong Jang  ;  Moonki Jung  ;  Jinuoung Kim  ;  Seok Hoon Jeong 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.9(6) : 1959, 2020-06 
Journal Title
 JOURNAL OF CLINICAL MEDICINE 
Issue Date
2020-06
Keywords
Korea centers for disease control and prevention (KCDC) classification ; angiotensin II receptor blockers (ARB) ; coronavirus disease-19 (COVID-19) ; ibuprofen ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Abstract
A rapid increase in the number of patients with coronavirus disease 19 (COVID-19) may overwhelm the available medical resources. We aimed to evaluate risk factors for disease severity in the early stages of COVID-19. The cohort comprised 293 patients with COVID-19 from 5 March 2020, to 18 March 2020. The Korea Centers for Disease Control and Prevention (KCDC) classification system was used to triage patients. The clinical course was summarized, including the impact of drugs (angiotensin II receptor blockers [ARB], ibuprofen, and dipeptidyl peptidase-4 inhibitors [DPP4i]) and the therapeutic effect of lopinavir/ritonavir. After adjusting for confounding variables, prior history of drug use, including ARB, ibuprofen, and DPP4i was not a risk factor associated with disease progression. Patients treated with lopinavir/ritonavir had significantly shorter progression-free survival than those not receiving lopinavir/ritonavir. KCDC classification I clearly distinguished the improvement/stabilization group from the progression group of COVID-19 patients (AUC 0.817; 95% CI, 0.740-0.895).
Files in This Item:
T202003826.pdf Download
DOI
10.3390/jcm9061959
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180046
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links