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Clinical-pathological prognostic factors and treatment failure patterns in T1-2 high-grade parotid gland cancer

Authors
 Young Min Park  ;  Sun Och Yoon  ;  Yoon Woo Koh  ;  Se-Heon Kim  ;  Jae-Yol Lim  ;  Eun Chang Choi 
Citation
 ORAL ONCOLOGY, Vol.110 : 104884, 2020-11 
Journal Title
 ORAL ONCOLOGY 
ISSN
 1368-8375 
Issue Date
2020-11
Keywords
Distant metastasis ; High-grade parotid gland cancer ; Lymph node metastasis ; Lymphovascular invasion
Abstract
Objectives: The purpose of this study was to evaluate the treatment outcomes of patients with T1-2, high-grade parotid cancer, and to analyze the prognostic factors and treatment failure patterns. Materials and methods: Of the 101 patients who were diagnosed with high-grade parotid cancer from March 2003 to December 2018, a total of 39 males and 23 females who had T1-2 tumor were enrolled in this study. Results: The average follow-up period of patients in this study was 63.9 months. The 5-year overall survival rate was 73.0%, and the 5-year disease-free survival rate was 57.6%. Thirty-nine patients underwent less-than-total parotidectomies, and the remaining 23 patients underwent total parotidectomies. After surgery, 50 patients received adjuvant treatment. During the study, 25 recurrences were documented, including nine local recurrences and 16 distant metastases. The average time period between the end of initial treatment and disease relapse was 17.0 months. A total of 16 patients succumbed to disease progression. Multivariate Cox proportional regression analysis showed that lymphovascular invasion (LVI) was an independent prognostic factor affecting disease recurrence and patient deaths. Among various factors, LVI and lymph node (LN) metastasis showed statistically significant correlations with distant metastasis. Conclusion: Although we achieved favorable therapeutic results using standard treatments in selected patients, T1-2 high-grade parotid cancers generally have poor prognosis. Distant metastases that occur during follow-up are a major factor in treatment failure and LVI and LN metastasis are significantly associated with distant metastasis.
Full Text
https://www.sciencedirect.com/science/article/pii/S1368837520303201
DOI
10.1016/j.oraloncology.2020.104884
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koh, Yoon Woo(고윤우)
Kim, Se Heon(김세헌)
Park, Young Min(박영민) ORCID logo https://orcid.org/0000-0002-7593-8461
Yoon, Sun Och(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
Lim, Jae Yol(임재열) ORCID logo https://orcid.org/0000-0002-9757-6414
Choi, Eun Chang(최은창)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180043
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