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Statins and metachronous recurrence after endoscopic resection of early gastric cancer: a nationwide Korean cohort study

Authors
 Hyunsoo Chung  ;  Hyun Ju Kim  ;  Hyun Chae Jung  ;  Sang Kil Lee  ;  Sang Gyun Kim 
Citation
 GASTRIC CANCER, Vol.23(4) : 659-666, 2020-07 
Journal Title
 GASTRIC CANCER 
ISSN
 1436-3291 
Issue Date
2020-07
Keywords
Endoscopic treatment ; Medication ; Recurrence ; Stomach neoplasm
Abstract
Background: Statins have shown to reduce the risk of various cancers. However, their effects on metachronous recurrence (MR) after endoscopic resection (ER) for early gastric cancer (EGC) are unknown. We evaluate their effects on MR development after ER for EGC. Methods: We selected 11,568 patients who received ER for EGC from 2002 to 2011 from the Korean National Health Insurance database and classified into 2 groups: control and statins using propensity score matching. Metachronous recurrence was defined as the second ER or gastrectomy performed 6 months after the first ER. Results: Mean follow-up period was 8.8 ± 3.1 years. Statins showed a significantly lower incidence of MR than the control group (12.5% vs 2.2%, respectively, P < 0.01). After conducting competing risk analyses and time-dependent cox regression analysis considering immortal time bias, statins still showed a lower incidence rate of MR compared to that observed in the control group. For the multivariate analysis, statins remained significant (HR 0.17; 95% CI 0.13-0.24, P < 0.01). In the dose-response analysis, an inverse dose-response relationship was identified between MR and statins (P < 0.01). Conclusion: Statins was significantly associated with a reduced risk of MR after ER for EGC with an inverse dose-response relationship.
Full Text
https://link.springer.com/article/10.1007/s10120-020-01041-z
DOI
10.1007/s10120-020-01041-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180028
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