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MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

Authors
 Karima Ait-Aissa  ;  Quynh My Nguyen  ;  Mohanad Gabani  ;  Adam Kassan  ;  Santosh Kumar  ;  Soo-Kyoung Choi  ;  Alexis A Gonzalez  ;  Tahsin Khataei  ;  Amal M Sahyoun  ;  Cheng Chen  ;  Modar Kassan 
Citation
 CARDIOVASCULAR DIABETOLOGY, Vol.19(1) : 136, 2020-09 
Journal Title
 CARDIOVASCULAR DIABETOLOGY 
Issue Date
2020-09
Keywords
Cardiovascular diseases ; Endothelial dysfunction ; MicroRNAs ; Obesity
Abstract
The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity perturbs the integrity of normal endothelium, leading to endothelial dysfunction which predisposes the patient to cardiovascular diseases. MicroRNAs (miRNAs) are short, single-stranded, non-coding RNA molecules that play important roles in a variety of cellular processes such as differentiation, proliferation, apoptosis, and stress response; their alteration contributes to the development of many pathologies including obesity. Mediators of obesity-induced endothelial dysfunction include altered endothelial nitric oxide synthase (eNOS), Sirtuin 1 (SIRT1), oxidative stress, autophagy machinery and endoplasmic reticulum (ER) stress. All of these factors have been shown to be either directly or indirectly caused by gene regulatory mechanisms of miRNAs. In this review, we aim to provide a comprehensive description of the therapeutic potential of miRNAs to treat obesity-induced endothelial dysfunction. This may lead to the identification of new targets for interventions that may prevent or delay the development of obesity-related cardiovascular disease.
Files in This Item:
T202003640.pdf Download
DOI
10.1186/s12933-020-01107-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Choi, Soo Kyoung(최수경) ORCID logo https://orcid.org/0000-0002-7115-6358
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180019
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