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Crohn's disease and ulcerative colitis are associated with different lipid profile disorders: a nationwide population-based study

Authors
 Hosim Soh  ;  Jong Pil Im  ;  Kyungdo Han  ;  Seona Park  ;  Seung Wook Hong  ;  Jeong Min Moon  ;  Eun Ae Kang  ;  Jaeyoung Chun  ;  Hyun Jung Lee  ;  Joo Sung Kim 
Citation
 ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol.51(4) : 446-456, 2020-02 
Journal Title
 ALIMENTARY PHARMACOLOGY & THERAPEUTICS 
ISSN
 0269-2813 
Issue Date
2020-02
MeSH
Adult ; Colitis, Ulcerative / blood ; Colitis, Ulcerative / epidemiology* ; Comorbidity ; Crohn Disease / blood ; Crohn Disease / epidemiology* ; Female ; Follow-Up Studies ; Humans ; Incidence ; Lipid Metabolism Disorders / blood ; Lipid Metabolism Disorders / epidemiology* ; Lipids / blood* ; Male ; Middle Aged ; Republic of Korea / epidemiology
Abstract
Background: The relationships between lipid profiles and IBD remain elusive. Aim: To determine the association of IBD with serum lipid profiles. Methods: A nationwide population-based study was performed using claims data from the Korean National Healthcare Insurance service. A total of 9 706 026 subjects undergoing medical check-ups in 2009 were enrolled and followed up until 2016. Individuals who developed Crohn's disease (CD) or ulcerative colitis (UC) were identified during follow-up. Adjusted hazard ratio (aHR) by age, sex, body mass index, cigarette smoking, alcohol drinking, exercise, income and underlying comorbidities was calculated to define the impact of serum lipid profiles on developing IBD. Results: During a median follow-up of 7.3 years, IBD was detected in 7,058 (0.07%) individuals. Compared with the highest quartile of serum total cholesterol (TC) levels, lower TC levels were associated with higher incidence of CD (aHR: Q1, 2.52; Q2, 1.52; Q3, 1.27), but not UC. Lower serum LDL-C levels were associated with higher incidence of CD (aHR: Q1, 1.92; Q2, 1.47; Q3, 1.22), but not UC. Moreover, lower serum HDL-C levels were associated with higher incidence of CD (aHR: Q1, 2.49; Q2, 1.90; Q3, 1.43), but not UC. In contrast, lower serum triglyceride levels were associated with higher incidence of UC (aHR: Q1, 1.22; Q2, 1.19; Q3, 1.19), but not CD. Conclusions: Low serum TC, LDL-C and HDL-C levels were associated with CD. Low serum triglyceride levels were related to UC.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/apt.15562
DOI
10.1111/apt.15562
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Chun, Jaeyoung(천재영) ORCID logo https://orcid.org/0000-0002-4212-0380
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180017
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