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Novel Insights into the Pathogenesis and Management of the Metabolic Syndrome

Authors
 Helen H Wang  ;  Dong Ki Lee  ;  Min Liu  ;  Piero Portincasa  ;  David Q-H Wang 
Citation
 PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION, Vol.23(3) : 189, 2020-05 
Journal Title
 PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION 
ISSN
 2234-8646 
Issue Date
2020-05
Keywords
Diabetes ; Dyslipidemia ; Hyperglycemia ; Insulin resistance ; Obesity
Abstract
The metabolic syndrome, by definition, is not a disease but is a clustering of individual metabolic risk factors including abdominal obesity, hyperglycemia, hypertriglyceridemia, hypertension, and low high-density lipoprotein cholesterol levels. These risk factors could dramatically increase the prevalence of type 2 diabetes and cardiovascular disease. The reported prevalence of the metabolic syndrome varies, greatly depending on the definition used, gender, age, socioeconomic status, and the ethnic background of study cohorts. Clinical and epidemiological studies have clearly demonstrated that the metabolic syndrome starts with central obesity. Because the prevalence of obesity has doubly increased worldwide over the past 30 years, the prevalence of the metabolic syndrome has markedly boosted in parallel. Therefore, obesity has been recognized as the leading cause for the metabolic syndrome since it is strongly associated with all metabolic risk factors. High prevalence of the metabolic syndrome is not unique to the USA and Europe and it is also increasing in most Asian countries. Insulin resistance has elucidated most, if not all, of the pathophysiology of the metabolic syndrome because it contributes to hyperglycemia. Furthermore, a major contributor to the development of insulin resistance is an overabundance of circulating fatty acids. Plasma fatty acids are derived mainly from the triglycerides stored in adipose tissues, which are released through the action of the cyclic AMP-dependent enzyme, hormone sensitive lipase. This review summarizes the latest concepts in the definition, pathogenesis, pathophysiology, and diagnosis of the metabolic syndrome, as well as its preventive measures and therapeutic strategies in children and adolescents.
Files in This Item:
T202003438.pdf Download
DOI
10.5223/pghn.2020.23.3.189
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Dong Ki(이동기) ORCID logo https://orcid.org/0000-0002-0048-9112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179939
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