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The risk of preterm birth in vanishing twin: A multicenter prospective cohort study

 Ji Su Seong  ;  You Jung Han  ;  Min Hyoung Kim  ;  Jae-Yoon Shim  ;  Mi-Young Lee  ;  Soo-Young Oh  ;  Joon Ho Lee  ;  Soo Hyun Kim  ;  Dong Hyun Cha  ;  Geum Joon Cho  ;  Han-Sung Kwon  ;  Byoung Jae Kim  ;  Mi Hye Park  ;  Hee Young Cho  ;  Hyun Sun Ko  ;  Chan-Wook Park  ;  Joong Shin Park  ;  Jong Kwan Jun  ;  Hyun Mee Ryu  ;  Seung Mi Lee 
 PLOS ONE, Vol.15(5) : e0233097, 2020-05 
Journal Title
Issue Date
Adult ; Body Mass Index ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Maternal Age ; Pregnancy ; Pregnancy, Twin ; Premature Birth / epidemiology* ; Premature Birth / etiology ; Prospective Studies ; Risk Factors
Objective: To evaluate not only the risk of total preterm birth (PTB) but also spontaneous preterm birth (sPTB) and indicated preterm birth (iPTB) in vanishing twin (VT).

Study design: This is a secondary analysis of a multicenter prospective cohort study. In 12 different healthcare institutions, women with singleton pregnancies were enrolled in early pregnancy and followed up till delivery.

Results: A total of 4,746 women were included in the final analysis, and. the frequency of VT was 1.1% (54/4746). VT group had a higher risk for total PTB (PTB<34 weeks, 2.1% vs. 14.8%, p<0.001; PTB<32 weeks, 1.6% vs. 13.0%, p<0.001; PTB<28 weeks, 0.9% vs. 13.0%, p<0.001) than singleton group. The VT group had increased risk for both sPTB and iPTB (<34 weeks, <32 weeks, and <28 weeks), and this increased risk for sPTB and iPTB in VT group remained significant even after controlling for confounders such as maternal age, parity, pre-pregnancy BMI, and mode of conception.

Conclusion: Vanishing twin can be an independent risk factor for both sPTB and iPTB when compared with singleton pregnancy.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Joon Ho(이준호)
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