Cited 1 times in
Cell Surface Antigen Display for Neuronal Differentiation-Specific Tracking
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조성래 | - |
dc.date.accessioned | 2020-11-17T05:03:11Z | - |
dc.date.available | 2020-11-17T05:03:11Z | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179870 | - |
dc.description.abstract | Cell therapeutic agents for treating degenerative brain diseases using neural stem cells are actively being developed. However, few systems have been developed to monitor in real time whether the transplanted neural stem cells are actually differentiated into neurons. Therefore, it is necessary to develop a technology capable of specifically monitoring neuronal differentiation in vivo. In this study, we established a system that expresses cell membrane-targeting red fluorescent protein under control of the Synapsin promoter in order to specifically monitor differentiation from neural stem cells into neurons. In order to overcome the weak expression level of the tissue-specific promoter system, the partial 5' UTR sequence of Creb was added for efficient expression of the cell surface-specific antigen. This system was able to track functional neuronal differentiation of neural stem cells transplanted in vivo, which will help improve stem cell therapies. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Applied Pharmacology | - |
dc.relation.isPartOf | BIOMOLECULES & THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Cell Surface Antigen Display for Neuronal Differentiation-Specific Tracking | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학교실) | - |
dc.contributor.googleauthor | Sang Chul Kim | - |
dc.contributor.googleauthor | Eun-Hye Lee | - |
dc.contributor.googleauthor | Ji Hea Yu | - |
dc.contributor.googleauthor | Sang-Mi Kim | - |
dc.contributor.googleauthor | Bae-Geun Nam | - |
dc.contributor.googleauthor | Hee Yong Chung | - |
dc.contributor.googleauthor | Yeon-Soo Kim | - |
dc.contributor.googleauthor | Sung-Rae Cho | - |
dc.contributor.googleauthor | Chang-Hwan Park | - |
dc.identifier.doi | 10.4062/biomolther.2018.110 | - |
dc.contributor.localId | A03831 | - |
dc.relation.journalcode | J00324 | - |
dc.identifier.eissn | 2005-4483 | - |
dc.identifier.pmid | 30458601 | - |
dc.subject.keyword | Differentiation | - |
dc.subject.keyword | In vivo monitoring | - |
dc.subject.keyword | Neuron specific | - |
dc.subject.keyword | Surface antigen | - |
dc.contributor.alternativeName | Cho, Sung Rae | - |
dc.contributor.affiliatedAuthor | 조성래 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 78 | - |
dc.citation.endPage | 84 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, Vol.27(1) : 78-84, 2019-01 | - |
dc.identifier.rimsid | 64982 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.