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Cell Surface Antigen Display for Neuronal Differentiation-Specific Tracking

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dc.contributor.author조성래-
dc.date.accessioned2020-11-17T05:03:11Z-
dc.date.available2020-11-17T05:03:11Z-
dc.date.issued2019-01-
dc.identifier.issn1976-9148-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179870-
dc.description.abstractCell therapeutic agents for treating degenerative brain diseases using neural stem cells are actively being developed. However, few systems have been developed to monitor in real time whether the transplanted neural stem cells are actually differentiated into neurons. Therefore, it is necessary to develop a technology capable of specifically monitoring neuronal differentiation in vivo. In this study, we established a system that expresses cell membrane-targeting red fluorescent protein under control of the Synapsin promoter in order to specifically monitor differentiation from neural stem cells into neurons. In order to overcome the weak expression level of the tissue-specific promoter system, the partial 5' UTR sequence of Creb was added for efficient expression of the cell surface-specific antigen. This system was able to track functional neuronal differentiation of neural stem cells transplanted in vivo, which will help improve stem cell therapies.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society of Applied Pharmacology-
dc.relation.isPartOfBIOMOLECULES & THERAPEUTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleCell Surface Antigen Display for Neuronal Differentiation-Specific Tracking-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Rehabilitation Medicine (재활의학교실)-
dc.contributor.googleauthorSang Chul Kim-
dc.contributor.googleauthorEun-Hye Lee-
dc.contributor.googleauthorJi Hea Yu-
dc.contributor.googleauthorSang-Mi Kim-
dc.contributor.googleauthorBae-Geun Nam-
dc.contributor.googleauthorHee Yong Chung-
dc.contributor.googleauthorYeon-Soo Kim-
dc.contributor.googleauthorSung-Rae Cho-
dc.contributor.googleauthorChang-Hwan Park-
dc.identifier.doi10.4062/biomolther.2018.110-
dc.contributor.localIdA03831-
dc.relation.journalcodeJ00324-
dc.identifier.eissn2005-4483-
dc.identifier.pmid30458601-
dc.subject.keywordDifferentiation-
dc.subject.keywordIn vivo monitoring-
dc.subject.keywordNeuron specific-
dc.subject.keywordSurface antigen-
dc.contributor.alternativeNameCho, Sung Rae-
dc.contributor.affiliatedAuthor조성래-
dc.citation.volume27-
dc.citation.number1-
dc.citation.startPage78-
dc.citation.endPage84-
dc.identifier.bibliographicCitationBIOMOLECULES & THERAPEUTICS, Vol.27(1) : 78-84, 2019-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers

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