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Ischemic and Bleeding Events Associated with Thrombocytopenia and Thrombocytosis after Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction

 Ji Woong Roh  ;  Sungmin Lim  ;  Youngdeok Hwang  ;  Kwan Yong Lee  ;  Eun Ho Choo  ;  Ik Jun Choi  ;  Byung-Hee Hwang  ;  Chan Joon Kim  ;  Mahn-Won Park  ;  Dong-Bin Kim  ;  Jong-Min Lee  ;  Chul Soo Park  ;  Hee-Yeol Kim  ;  Ki-Dong Yoo  ;  Doo Soo Jeon  ;  Ho Joong Youn  ;  Wook Sung Chung  ;  Min Chul Kim  ;  Myung Ho Jeong  ;  Youngkeun Ahn  ;  Kiyuk Chang 
 JOURNAL OF CLINICAL MEDICINE, Vol.9(10) : 3370, 2020-10 
Journal Title
Issue Date
acute myocardial infarction ; percutaneous coronary intervention ; thrombocytopenia ; thrombocytosis
The early and late ischemic and bleeding clinical outcomes according to baseline platelet count after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) remain unclear. Overall, 10,667 patients from the Cardiovascular Risk and identification of potential high-risk population in AMI (COREA-AMI) I and II registries were classified according to the following universal criteria on baseline platelet counts: (1) moderate to severe thrombocytopenia (platelet < 100 K/μL, n = 101), (2) mild thrombocytopenia (platelet = 100~149 K/μL, n = 631), (3) normal reference (platelet = 150~450 K/μL, n = 9832), and (4) thrombocytosis (platelet > 450 K/μL, n = 103). The primary endpoint was the occurrence of major adverse cardiovascular events (MACE). The secondary outcome was Bleeding Academic Research Consortium (BARC) 2, 3, and 5 bleeding. After adjusting for confounders, the moderate to severe thrombocytopenia (HR, 2.03; 95% CI, 1.49-2.78); p < 0.001), mild thrombocytopenia (HR, 1.15; 95% CI, 1.01-1.34; p = 0.045), and thrombocytosis groups (HR, 1.47; 95% CI, 1.07-2.03; p = 0.019) showed higher 5-year MACE rates than the normal reference. In BARC 2, 3, and 5 bleeding outcomes, the bleedings rates were higher than the normal range in the moderate to severe thrombocytopenia (HR, 2.18; 95% CI, 1.36-3.49; p = 0.001) and mild thrombocytopenia (HR, 1.41; 95% CI, 1.12-1.78; p = 0.004) groups. Patients with AMI had higher 5-year MACE rates after PCI if they had lower- or higher-than-normal platelet counts. Thrombocytopenia revealed higher early and late bleeding rates whereas thrombocytosis showed long-term bleeding trends, although these trends were not statistically significant.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Roh, Ji Woong(노지웅)
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