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Gastric subtype of intraductal papillary neoplasm of the bile duct: The pathologic spectrum

Authors
 Yasuni Nakanuma  ;  Katsuhiko Uesaka  ;  Takuro Terada  ;  Yukie Fukumura  ;  Takashi Sugino  ;  Yuko Kakuda  ;  Hiroko Ikeda  ;  Kenichi Harada  ;  Yasunori Sato  ;  Shinichiro Shimizu  ;  Susumu Matsukuma  ;  Jang Kee Taek  ;  Young Nyun Park 
Citation
 JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Vol.27(7) : 402-413, 2020-07 
Journal Title
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
ISSN
 1868-6974 
Issue Date
2020-07
Keywords
foveola ; gastric differentiation ; intraductal papillary neoplasm of bile duct ; pancreas ; pyloric gland
Abstract
Background and aims: Intraductal papillary neoplasms of bile duct (IPNBs) remain a challenging entity to manage.

Methods: The pathologic spectrum of 34 gastric subtype of IPNB (gIPNB) cases was examined in consideration of the type 1 and 2 subclassification proposed by Japan-Korea consensus and compared with gastric subtype of pancreatic intraductal papillary mucinous neoplasm (gIPMN) (44 cases).

Results: Type 1 gIPNBs (17 cases) showed regular papillary foveola with variable tubular pyloric glands. Eight of the type 1 gIPNBs showed low-grade dysplasia. Type 2 cases (n = 17) showed complicated papillary and tubular structures and high-grade dysplastic foveola and pyloric glands. Foveolas were predominant in 15 cases, while pyloric glands were predominant in 10 cases, and considerable areas of foveolas and pyloric glands in the remaining: these three were found similarly in type 1 and 2 gIPNB. gIPMNs showed central foveola with a peripheral pyloric gland. Such a pattern was recognizable in type 1 but vague in type 2. Type 1 was frequently found in the intrahepatic bile ducts and showed abundant mucin, as in gIPMNs, while type 2 also occurred in the extrahepatic bile ducts and were pathologically more malignant.

Conclusion: Type 1 lesions shared features of gIPMN, while type 2 lesions differed from gIPMN and were more pathologically malignant.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/jhbp.751
DOI
10.1002/jhbp.751
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179552
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