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One-year efficacy and safety of everolimus-eluting bioresorbable scaffolds in the setting of acute myocardial infarction

 Yongcheol Kim  ;  SungA Bae  ;  Myung Ho Jeong  ;  Youngkeun Ahn  ;  Chong Jin Kim  ;  Myeong Chan Cho  ;  Andreas Baumbach  ;  Bill D Gogas  ;  Spencer B King 3rd  ;  Other Korea Acute Myocardial Infarction Registry Investigators 
 PLOS ONE, Vol.15(7) : e0235673, 2020-07 
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Background and objectives: This study sought to compare clinical outcomes between bioresorbable scaffolds (BRS) and durable polymer everolimus-eluting metallic stents (DP-EES) in patients with acute myocardial infarction (AMI) undergoing successful percutaneous coronary intervention (PCI).

Methods: From March 2016 to October 2017, 952 patients with AMI without cardiogenic shock undergoing successful PCI with BRS (n = 136) or DP-EES (n = 816) were enrolled from a multicenter, observational Korea Acute Myocardial Infarction Registry.

Results: In the crude population, there was no significant difference in the 1-year rate of device-oriented composite endpoint (DOCE) and device thrombosis between the BRS and DP-EES groups (2.2% vs. 4.8%, hazard ratio [HR] 0.43, 95% confidence interval [CI] 0.13-1.41, p = 0.163; 0.7% vs. 0.5%, HR 1.49, 95% CI 0.16-13.4, p = 0.719, respectively). BRS implantation was opted in younger patients (53.7 vs. 62.6 years, p < 0.001) with low-risk profiles, and intravascular image-guided PCI was more preferred in the BRS group (60.3% vs. 27.2%, p < 0.001).

Conclusions: At 1-year follow-up, no differences in the rate of DOCE and device thrombosis were observed between patients with AMI treated with BRS and those treated with DP-EES. Our data suggest that imaging-guided BRS implantation in young patients with low risk profiles could be a reasonable strategy in the setting of AMI.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yongcheol(김용철) ORCID logo https://orcid.org/0000-0001-5568-4161
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