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Prognostic significance of lymphovascular invasion in patients with salivary duct cell carcinoma of the head and neck

Authors
 Y M Park  ;  M A AlHashim  ;  S O Yoon  ;  Y W Koh  ;  S-H Kim  ;  J Y Lim  ;  E C Choi 
Citation
 INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, Vol.49(6) : 693-699, 2020-06 
Journal Title
 INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 
ISSN
 0901-5027 
Issue Date
2020-06
MeSH
Humans ; Lymphatic Metastasis ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Salivary Ducts* ; Salivary Gland Neoplasms* ; Survival Rate
Keywords
lymphovascular invasion ; prognosis ; salivary duct cell carcinoma
Abstract
The purpose of this study was to evaluate the treatment outcomes of patients who underwent surgery with curative intention after the diagnosis of salivary duct cell carcinoma (SDC) in the head and neck area and to analyse the prognostic factors and treatment failure pattern. Fifty-nine patients treated between March 2003 and December 2018 were enrolled in the study. The mean follow-up period was 45.5 months (range 12-189 months). The 5-year overall survival rate was 54.7% and the 5-year disease-free survival rate was 56.8%. Nineteen recurrences occurred during the study period: four loco-regional recurrences and 15 distant metastases. During the study period, 10 patients died of disease relapse and 5 patients died of other medical caused. On univariate analysis, lymphovascular invasion (LVI) (P=0.031) showed the most significant correlation with mortality. On multivariate Cox regression analysis, LVI showed the most significant correlation with patient survival (P = 0.027). LVI was the most significant prognostic factor related to the 5-year overall survival rate of SDC patients. The development of novel therapeutic agents is necessary to improve the survival rate of these patients with LVI.
Full Text
https://www.sciencedirect.com/science/article/pii/S0901502719314055
DOI
10.1016/j.ijom.2019.11.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koh, Yoon Woo(고윤우)
Kim, Se Heon(김세헌)
Park, Young Min(박영민) ORCID logo https://orcid.org/0000-0002-7593-8461
Yoon, Sun Och(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
Lim, Jae Yol(임재열) ORCID logo https://orcid.org/0000-0002-9757-6414
Choi, Eun Chang(최은창)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179417
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