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Precision Therapy in Acromegaly Caused by Pituitary Tumors: How Close Is It to Reality?

Authors
 Cheol Ryong Ku  ;  Vladimir Melnikov  ;  Zhaoyun Zhang  ;  Eun Jig Lee 
Citation
 Endocrinology and Metabolism (대한내분비학회지), Vol.35(2) : 206-216, 2020-06 
Journal Title
 Endocrinology and Metabolism (대한내분비학회지) 
ISSN
 2093-596X 
Issue Date
2020-06
Keywords
Growth hormone ; Pituitary neoplasms ; Precision medicine ; Acromegaly
Abstract
Acromegaly presents with an enigmatic range of symptoms and comorbidities caused by chronic and progressive growth hormone elevations, commonly due to endocrinologic hypersecretion from a pituitary gland tumor. Comprehensive national acromegaly databases have been appearing over the years, allowing for international comparisons of data, although still presenting varying prevalence and incidence rates. Lack of large-scale analysis in geographical and ethnic differences in clinical presentation and management requires further research. Assessment of current and novel predictors of responsiveness to distinct therapy can lead to multilevel categorization of patients, allowing integration into new clinical guidelines and reduction of increased morbidity and mortality associated with acromegaly. This review compares current data from epidemiological studies and assesses the present-day application of prognostic factors in medical practice, the reality of precision therapy, as well as its future prospects in acromegaly, with a special focus on its relevance to the South Korean population.
Files in This Item:
T202002605.pdf Download
DOI
10.3803/EnM.2020.35.2.206
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Cheol Ryong(구철룡) ORCID logo https://orcid.org/0000-0001-8693-9630
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179377
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