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Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use

Authors
 Bo Kyu Choi  ;  Kyeongyeol Cheon  ;  Bang Hoon Cho  ;  Jae Wook Jung  ;  Kyung Yul Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.61(6) : 553-555, 2020-06 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2020-06
MeSH
5-alpha Reductase Inhibitors / adverse effects ; Adult ; Cerebral Veins / pathology* ; Dutasteride / adverse effects* ; Fundus Oculi ; Humans ; Magnetic Resonance Imaging ; Male ; Risk Factors ; Sinus Thrombosis, Intracranial / chemically induced*
Keywords
5-alpha reductase inhibitors ; Alopecia ; venous thrombosis
Abstract
Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults with known risk factors of prothrombotic conditions, pregnancy, infection, malignancy, and drugs. Dutasteride is a 5α-reductase inhibitor that is used for benign prostate hypertrophy and androgenetic alopecia. To date, CVT caused by dutasteride use has not been reported. A 25-year-old male presented with headache and diplopia. He had taken 0.5 mg of dutasteride every other day for 9 months to treat alopecia. A headache developed 7 months after he started taking medication, and horizontal diplopia occurred 1 month after the onset of headache. Fundus examination showed bilateral papilledema. Brain magnetic resonance imaging showed thrombosis in the left sigmoid and transverse sinuses. Headache and diplopia improved after discontinuing dutasteride and starting anticoagulation. The results from this case report indicated dutasteride as a potential cause of CVT. Presumably, the increased estrogen level due to dutasteride use caused the formation of a thrombus.
Files in This Item:
T202002652.pdf Download
DOI
10.3349/ymj.2020.61.6.553
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179346
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