17 22

Cited 0 times in

Homer2 regulates amylase secretion via physiological calcium oscillations in mouse parotid gland acinar cells

DC FieldValueLanguage
dc.contributor.author양유미-
dc.contributor.author신동민-
dc.date.accessioned2020-09-28T12:00:37Z-
dc.date.available2020-09-28T12:00:37Z-
dc.date.issued2020-06-
dc.identifier.issn1226-7155-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179314-
dc.description.abstractThe salivary glands secrete saliva, which plays a role in the maintenance of a healthy oral environment. Under physiological conditions, saliva secretion within the acinar cells of the gland is regulated by stimulation of specific calcium (Ca2+) signaling mechanisms such as increases in the intracellular Ca2+ concentration ([Ca2+]i) via storeoperated Ca2+ entry, which involves components such as Orai1, transient receptor potential (TRP) canonical 1, stromal interaction molecules, and inositol 1,4,5-triphosphate (IP3) receptors (IP3Rs). Homer proteins are scaffold proteins that bind to G protein-coupled receptors, IP3Rs, ryanodine receptors, and TRP channels. However, their exact role in Ca2+ signaling in the salivary glands remains unknown. In the present study, we investigated the role of Homer2 in Ca2+ signaling and saliva secretion in parotid gland acinar cells under physiological conditions. Deletion of Homer2 (Homer2−/−) markedly decreased the amplitude of [Ca2+]i oscillations via the stimulation of carbachol, which is physiologically concentrated in parotid acinar cells, whereas the frequency of [Ca2+]i oscillations showed no difference between wild-type and Homer2−/− mice. Homer2−/− mice also showed a significant decrease in amylase release by carbachol in the parotid gland in a dose-dependent manner. These results suggest that Homer2 plays a critical role in maintaining [Ca2+]i concentration and secretion of saliva in mouse parotid gland acinar cells.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherHarn Rim Won Printing Co.-
dc.relation.isPartOfInternational Journal of Oral Biology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHomer2 regulates amylase secretion via physiological calcium oscillations in mouse parotid gland acinar cells-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorNamju Kang1,2, Jung Yun Kang1,2, Dong Min Shin1*, Yu-Mi Yang1*-
dc.identifier.doi10.11620/IJOB.2020.45.2.58-
dc.contributor.localIdA05148-
dc.contributor.localIdA02091-
dc.contributor.localIdA02091-
dc.relation.journalcodeJ01144-
dc.subject.keywordCalcium signaling-
dc.subject.keywordSalivation-
dc.subject.keywordAcinar cells-
dc.subject.keywordPhysiological phenomena-
dc.contributor.alternativeNameYang, Yu Mi-
dc.contributor.affiliatedAuthor양유미-
dc.contributor.affiliatedAuthor신동민-
dc.contributor.affiliatedAuthor신동민-
dc.citation.volume45-
dc.citation.number2-
dc.citation.startPage58-
dc.citation.endPage63-
dc.identifier.bibliographicCitationInternational Journal of Oral Biology, Vol.45(2) : 58-63, 2020-06-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.