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Homer2 regulates amylase secretion via physiological calcium oscillations in mouse parotid gland acinar cells
DC Field | Value | Language |
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dc.contributor.author | 양유미 | - |
dc.contributor.author | 신동민 | - |
dc.date.accessioned | 2020-09-28T12:00:37Z | - |
dc.date.available | 2020-09-28T12:00:37Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 1226-7155 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179314 | - |
dc.description.abstract | The salivary glands secrete saliva, which plays a role in the maintenance of a healthy oral environment. Under physiological conditions, saliva secretion within the acinar cells of the gland is regulated by stimulation of specific calcium (Ca2+) signaling mechanisms such as increases in the intracellular Ca2+ concentration ([Ca2+]i) via storeoperated Ca2+ entry, which involves components such as Orai1, transient receptor potential (TRP) canonical 1, stromal interaction molecules, and inositol 1,4,5-triphosphate (IP3) receptors (IP3Rs). Homer proteins are scaffold proteins that bind to G protein-coupled receptors, IP3Rs, ryanodine receptors, and TRP channels. However, their exact role in Ca2+ signaling in the salivary glands remains unknown. In the present study, we investigated the role of Homer2 in Ca2+ signaling and saliva secretion in parotid gland acinar cells under physiological conditions. Deletion of Homer2 (Homer2−/−) markedly decreased the amplitude of [Ca2+]i oscillations via the stimulation of carbachol, which is physiologically concentrated in parotid acinar cells, whereas the frequency of [Ca2+]i oscillations showed no difference between wild-type and Homer2−/− mice. Homer2−/− mice also showed a significant decrease in amylase release by carbachol in the parotid gland in a dose-dependent manner. These results suggest that Homer2 plays a critical role in maintaining [Ca2+]i concentration and secretion of saliva in mouse parotid gland acinar cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Harn Rim Won Printing Co. | - |
dc.relation.isPartOf | International Journal of Oral Biology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Homer2 regulates amylase secretion via physiological calcium oscillations in mouse parotid gland acinar cells | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Namju Kang1,2, Jung Yun Kang1,2, Dong Min Shin1*, Yu-Mi Yang1* | - |
dc.identifier.doi | 10.11620/IJOB.2020.45.2.58 | - |
dc.contributor.localId | A05148 | - |
dc.contributor.localId | A02091 | - |
dc.relation.journalcode | J01144 | - |
dc.subject.keyword | Calcium signaling | - |
dc.subject.keyword | Salivation | - |
dc.subject.keyword | Acinar cells | - |
dc.subject.keyword | Physiological phenomena | - |
dc.contributor.alternativeName | Yang, Yu Mi | - |
dc.contributor.affiliatedAuthor | 양유미 | - |
dc.contributor.affiliatedAuthor | 신동민 | - |
dc.citation.volume | 45 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 58 | - |
dc.citation.endPage | 63 | - |
dc.identifier.bibliographicCitation | International Journal of Oral Biology, Vol.45(2) : 58-63, 2020-06 | - |
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