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Clinical impact of pre-hypertension on the risk of cancer in male and female subjects

 Su Hwan Lee  ;  Hye Ah Lee  ;  Sean S Lee  ;  Seong-Eun Kim  ;  Ki-Nam Shim  ;  Hye-Kyung Jung  ;  Sung-Ae Jung  ;  Jung Hyun Chang  ;  Kihwan Kwon  ;  Wook Bum Pyun  ;  Boyoung Joung  ;  Chang Mo Moon  ;  Junbeom Park 
 SCIENTIFIC REPORTS, Vol.10(1) : 9974, 2020-06 
Journal Title
Issue Date
There are few studies assessing pre-hypertension and an impaired fasting glucose (IFG) and their combined effects on the cancer risk. We investigated the impact of pre-hypertension on cancer risk and IFG, and their combined effects on the cancer risk. This study included 371,762 subjects (≥40 years) who had never been diagnosed with hypertension, diabetes mellitus (DM), and cancer before. During a mean follow-up of 10.06 ± 1.86 years, 35,605 (9.58%) of the subjects developed cancer. In men only, cancer risk was significantly increased with an increase in the blood pressure (BP) (P for trend < 0.001), and were increased in the hypertension range, but not the pre-hypertension range. When analyzing the combination effect of BP and fasting glucose, cancer risks were serially increased with an increase in the fasting glucose in a dose-dependent manner, but not with an increase in BP. These results were more consistently significant in the never-smoker and non-alcohol drinking groups. However, in women, there was no significant difference. In conclusions, increased BP status or the fasting serum glucose level status were associated with cancer risk in men. Furthermore, the combination of both pre-hypertension and IFG also was associated with a cancer risk in men.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Su Hwan(이수환) ORCID logo https://orcid.org/0000-0002-3487-2574
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
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