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비만세포에 대한 병리조직검사를 통한 아나필락시스성 쇼크의 사후 진단

Other Titles
 Postmortem Diagnosis of Anaphylactic Shock by Histopathological Examination of Mast Cell 
 박종필  ;  구본영  ;  이낙원 
 Korean Journal of Legal Medicine (대한법의학회지), Vol.44(2) : 76-83, 2020-05 
Journal Title
 Korean Journal of Legal Medicine (대한법의학회지) 
Issue Date
Anaphylaxis ; Mast cells ; Autopsy ; Pathology
An autopsy for a fatal anaphylactic shock (AS) is not rare; however, postmortem diagnosis of anaphylaxis can be very challenging due to nonspecific macroscopic findings and absence of diagnostic tests except serum mast cell tryptase analysis. We tried to review the usefulness of histopathologic examination as an alternative method for the postmortem diagnosis of AS in this study. Immunohistochemical staining was carried out for detection of mast cells in 27 autopsy cases, including 7 AS cases, 5 false-positive cases, and 15 control cases at the National Forensic Service from January 2013 to May 2015, and the differences of mast cell counts and staining pattern were analyzed. The results revealed no differences in the number of mast cells among the three groups; however, a characteristic mast cell degranulation staining pattern was observed in the AS group and false-positive group. It can be conclusively inferred that the histopathologic examination could prove helpful in the postmortem diagnosis of AS, but it should serve as an ancillary option.
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1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
Yonsei Authors
Park, Jong Pil(박종필) ORCID logo https://orcid.org/0000-0002-6525-3012
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