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Comorbidities in ANCA-associated vasculitis

Authors
 Andreas Kronbichler  ;  Johannes Leierer  ;  Philipp Gauckler  ;  Jae Il Shin 
Citation
 RHEUMATOLOGY, Vol.59(Suppl. 3) : iii79-iii83, 2020-05 
Journal Title
 RHEUMATOLOGY 
ISSN
 1462-0324 
Issue Date
2020-05
Keywords
comorbidity ; coronary heart disease ; deep vein thrombosis ; diabetes mellitus ; hypercholesterolaemia ; hypertension ; myocardial infarction ; pulmonary embolism ; vasculitis
Abstract
The prognosis of patients with ANCA-associated vasculitis has improved over the past decades, but overall survival rates are still unsatisfactory. Recent research has focused on complications of immunosuppressive measures and comorbidities of ANCA-associated vasculitis. This review focuses on thromboembolic and cardiovascular events. A considerably increased risk of thromboembolic events has been reported, which is associated with active disease and impaired coagulation factors. There is mounting evidence that a hypercoagulable state is present even in patients in remission, and studies investigating the impact of tailored anticoagulation are needed to reduce the burden of thromboembolism. Cardiovascular mortality is one of the leading causes of death and accelerated atherosclerosis is frequently observed in patients with ANCA-associated vasculitis. A high frequency of patients develops hypertension, diabetes mellitus and hypercholesterolaemia, either as a consequence of immunosuppression or associated with the underlying disease. The current control of modifiable cardiovascular risk factors is insufficient and thorough reviews should be performed periodically. Treatment of these risk factors should be adopted according to current recommendations related to individual cardiovascular risk prediction.
Files in This Item:
T202002286.pdf Download
DOI
10.1093/rheumatology/kez617
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179183
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